SSRIs and PPHN: Are We Any Closer to Calculating the Risk?
The PPHN story has been a bit of a rollercoaster. Just to review…
Antidepressants and Pregnancy: A Meta-Analysis Puts the Risks into a Larger Context
While some studies have shown an association between in utero exposure to antidepressants and various pregnancy outcomes, including preterm delivery, low birth weight, and lower Apgar scores, these outcomes have also been linked to untreated maternal depression. Thus, it has been difficult to determine if there is a causal relationship between antidepressant exposure and negative pregnancy outcomes or whether maternal depression is itself responsible for these negative outcomes.