estrogen - MGH Center for Women's Mental Health

Soy Supplements: No Effect on Cognition in Postmenopausal Women

Soy-based products have long been touted as a treatment for menopausal symptoms. However, many of the clinical studies measuring the effectiveness of dietary sources of soy isoflavones (e.g., soy beverages, soy powder) for the treatment of menopausal vasomotor symptoms (i.e., hot flushes, night sweats) have been negative. Less is known about the effects of soy on cognition. A large clinical trial suggests that soy may not have any positive effects on cognition in postmenopausal women.

By MGH Center for Women's Mental Health|2015-08-12T12:31:30-04:00July 18th, 2012|Alternative & Complementary, Cognition, Menopausal Symptoms, Treatment|Comments Off

Red Ginseng May Help with Menopausal Symptoms But Is It A Good Choice for All Women?

By MGH Center for Women's Mental Health|2015-08-12T14:34:20-04:00June 19th, 2012|Alternative & Complementary, Menopausal Symptoms, Treatment, Vasomotor Symptoms|Comments Off

In Brief: Menopausal Symptoms Usually Go Untreated

In this study, half of women aged 45 to 60 years reported experiencing menopausal symptoms. 69% of these women reported that their symptoms have negatively affected their lives. Among the women who endorsed menopausal symptoms, 72% had not received any treatment for their symptoms and 77% reported that they had not discussed treatment options with their healthcare providers.

By MGH Center for Women's Mental Health|2016-07-22T13:44:53-04:00June 18th, 2012|Depressive Disorders, Menopausal Symptoms, Treatment, Vasomotor Symptoms|Comments Off

A New Website to Help Educate Menopausal Women about Their Treatment Options

Ever since 2002 when several large-scale studies called into question the safety of long-term hormone replacement therapy (HRT), there has been confusion and conflicting opinions regarding the management of menopausal symptoms. Initially there was a movement to avoid HRT altogether; now it is becoming clearer that certain women may safely use and benefit from hormonal interventions.

By MGH Center for Women's Mental Health|2015-08-12T15:19:31-04:00May 31st, 2012|Menopausal Symptoms, Resources|Comments Off

New Research from the CWMH: Progestins Do Not Negatively Affect Mood in Peri- and Postmenopausal Women

More than half of all women initiating treatment with hormone therapy will stop within the first year of treatment, most often because of side effects. Mood disturbance is a relatively common side effect that occurs with hormone therapy, and previous studies have suggested that progestins in the combined hormone preparations are responsible for these negative mood effects.

By MGH Center for Women's Mental Health|2016-03-28T13:02:53-04:00May 30th, 2012|Depressive Disorders, Hormone Therapy, Menopausal Symptoms, Prevalence & Risk Factors, Research at CWMH|Comments Off

Heavy Menstrual Bleeding More Common in Midlife Women with Histories of Depression

Menstrual problems are common among premenopausal women and become more frequent with increasing reproductive age, especially just before and during perimenopause. In the Study of Women's Health Across the Nation, a multisite study of menopause and aging, information regarding menstrual history was collected in a total of 934 premenopausal and early perimenopausal women between the ages of 42 and 52. History of major depression was associated with an increased likelihood of heavy bleeding (odds ratio, 1.89), adjusting for recent major depression, menopause status, and other confounding factors. History of depression was not associated with other abnormal bleeding or premenstrual symptoms. Future longitudinal studies are needed to explore why past depression increases the likelihood of subsequent heavy menstrual bleeding in midlife women. One possibility is that irregular fluctuations in estrogen levels may be responsible for both abnormal menstrual bleeding, as well as the dysregulation of neurotransmitter systems that mediate depressive symptoms.

By MGH Center for Women's Mental Health|2015-08-12T16:16:56-04:00May 22nd, 2012|Depressive Disorders, Menopausal Symptoms, Prevalence & Risk Factors|Comments Off

NAMS Supports the Use of Hormone Therapy in Perimenopausal and Recently Postmenopausal Women

The North American Menopause Society (NAMS) has updated its 2010 recommendations regarding the use of postmenopausal hormone therapy (HT) based on evidence accumulated subsequent to the previous report. In the decade since the first publication of the results from the Women's Health Initiative, we have accumulated evidence to indicate that multiple factors influence the effects of hormone therapy, including the type of estrogen used, the way the hormones are given, and the age and recency of menopause of the woman taking the medication. These factors also determine the risks associated with hormone therapy.

By MGH Center for Women's Mental Health|2015-08-12T16:42:55-04:00March 21st, 2012|Hormone Therapy, Menopausal Symptoms, Treatment, Vasomotor Symptoms|Comments Off

Raloxifene as Adjunctive Treatment for Postmenopausal Women with Schizophrenia

A few years ago on our blog, we reviewed a paper suggesting that estrogen may be a beneficial treatment for women with schizophrenia. In this study patients with schizophrenia receiving estrogen showed significant improvement in their positive symptoms (hallucinations, delusions), but no difference in negative symptoms (reduction in range of emotional expression, poverty of speech, lack of motivation).1, 2 Additional studies have also found estrogen to be effective in improving positive and general symptoms in patients with schizophrenia. 3, 4

By MGH Center for Women's Mental Health|2015-08-12T16:53:07-04:00February 13th, 2012|Menopausal Symptoms, Schizophrenia and Psychotic Disorders, Treatment|Comments Off

The Truth About Bioidentical Hormones

In increasing numbers, women who are candidates for hormonal replacement therapy are requesting “bioidentical” rather than synthetic hormones. Although there is a tendency to think of bioidentical hormones as “all-natural”, they, like synthetic hormones, are manufactured in the laboratory. In contrast to synthetic hormones, they are chemically identical to the hormones produced by the human body; synthetic hormones are structurally different yet are designed to have similar biological effects as naturally produced hormones.

By MGH Center for Women's Mental Health|2015-04-14T22:59:40-04:00November 23rd, 2009|Hormone Therapy, Menopausal Symptoms, Treatment, Vasomotor Symptoms|Comments Off

Estrogen for the Treatment of Women with Schizophrenia

There is cumulative evidence suggesting that estrogen might play a role in the development of schizophrenia and therefore may be useful in the treatment of this illness. On average, the first signs of schizophrenia appear 3 to 4 years later in women than in men, with a second peak in women around menopause. Interestingly, men suffering from schizophrenia exacerbation demonstrate low serum estrogen and androgen levels. Estrogen has been demonstrated to have beneficial effects in treating hormonally mediated affective disorders such as postnatal depression or perimenopausal depression. A recent study published in the Archives of General Psychiatry suggests that estrogen may also be beneficial for the treatment of patients with schizophrenia.

By MGH Center for Women's Mental Health|2015-08-11T14:46:54-04:00September 22nd, 2008|Hormone Therapy, Menopausal Symptoms, Schizophrenia and Psychotic Disorders, Treatment|Comments Off