allopregnanolone - MGH Center for Women's Mental Health

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD). SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of [...]

By MGH Center for Women's Mental Health|2019-01-13T15:57:09-04:00January 14th, 2019|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off

New Study at the CWMH: Brexanolone (SAGE-547) for Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression. SAGE-547, now called brexanolone, is a new type of antidepressant: a formulation of allopregnanolone, which is [...]

By MGH Center for Women's Mental Health|2017-07-03T13:52:30-04:00June 22nd, 2017|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off

Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression. SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors. This drug was initially under [...]

By MGH Center for Women's Mental Health|2017-05-10T09:40:41-04:00May 10th, 2017|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off