Pregabalin (marketed in the US as Lyrica) is approved by the US Food and Drug Administration for the treatment of epilepsy, fibromyalgia, and neuropathic pain. Â It is also used off-label to treat psychiatric disorders, most [...]
Postpartum psychosis (PPP) is a serious condition, occurring in 1 to 2 per 1000 women in the weeks after delivery and associated with extreme delirium-like behavior, delusions, hallucinations, and an increased risk of suicide and [...]
In our clinic, we are seeing more and more women of reproductive age using marijuana in various forms. Â According to research published in the Journal of the American Medical Association, there has been a significant [...]
Two new studies explore the efficacy of non-pharmacologic treatments for depression during pregnancy. The first uses internet-derived cognitive behavioral therapy (Loughnan et al, 2018) in a group of pregnant women with anxiety and/or depression. The [...]
This week’s offering includes an article published in Pediatrics indicating that cannabis metabolites are found in the breast milk up to 6 days after the last use.  A small prospective study from Wisner and colleagues [...]
In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression (PPD). Â SAGE-547, now called brexanolone, is an allosteric modulator of GABA-A receptors. Â We saw the preliminary [...]
August 23, 2018 from ObGynNews The management of bipolar disorder during pregnancy is a critical clinical situation demanding great attention to issues such as reproductive safety of psychiatric medications used by women with bipolar disorder [...]
Data on the most recent randomized controlled trial of brexanolone, a novel treatment for postpartum depression, were released. (We will review those in greater detail next week.) Â Â Guidelines for the treatment of perimenopausal depression were [...]
Psychiatric Medications and Reproductive Safety: Scientific and Clinical Perspectives Pertaining to the US FDA Pregnancy and Lactation Labeling Rule. Freeman MP, Farchione T, Yao L, Sahin L, Taylor L, Huybrechts KF, Nonacs R, Sosinsky AZ, [...]
A recent article published in JAMA Internal Medicine raises concerns regarding the increasing use of marijuana in pregnant women. Â According to data derived from two small surveys, women reported using marijuana to alleviate morning sickness, [...]
