MGH Center for Women's Mental Health

Prevention of Postpartum Depression

Postpartum depression (PPD) is a relatively common problem, affecting between 10% and 15% of women after delivery. Although it is difficult to reliably predict which women in the general population will experience postpartum mood disturbance, it is possible to identify certain subgroups of women who are more vulnerable to postpartum affective illness. Women who have had one episode of postpartum depression have about a 50% chance of experiencing another episode of PPD after a subsequent pregnancy. The extent to which a history of depression (prior to pregnancy) influences risk is less clear, but some studies indicate that between 30% and 50% will suffer from recurrent depression during the postpartum period. Several investigators have recently explored the potential efficacy of prophylactic interventions in these populations of women at risk.

By MGH Center for Women's Mental Health|2015-08-07T22:57:38-04:00July 20th, 2004|Postpartum Depression, Postpartum Psychiatric Disorders, Prevention|Comments Off

Is St. John’s Wort Safe in Breastfeeding Women?

Postpartum depression is a relatively common event, affecting 10 to 15% of women after the birth of a child. Many women, however, do not receive treatment, and one of the most common reasons for avoiding or deferring treatment is concern regarding the use of medications while breastfeeding. A preliminary study from Lee and colleagues at the Motherisk Program in Toronto, Canada has investigated the use of St. John’s wort in breastfeeding women.

By MGH Center for Women's Mental Health|2015-07-21T11:28:28-04:00January 18th, 2004|Antidepressants, Breastfeeding & Medications|Comments Off

Long-term Effects of Fetal Exposure to Antidepressants

Although data accumulated over the last 30 years suggest that some medications may be used safely during pregnancy, our knowledge regarding the risks of prenatal exposure to psychotropic medications is incomplete. Because neuronal migration and differentiation occur throughout pregnancy and into the early years of life, the central nervous system (CNS) remains particularly vulnerable to toxic agents throughout pregnancy. While insults that occur early in pregnancy may result in gross abnormalities, exposures that occur after neural tube closure (at 32 days of gestation) may produce more subtle changes in behavior and functioning.

By MGH Center for Women's Mental Health|2015-07-21T11:25:18-04:00March 31st, 2003|Antidepressants, Child Outcomes, Long-Term Outcomes, Pregnancy & Medications|Comments Off

Bupropion and Breastfeeding

Data have accumulated over the last few years on the use of antidepressants in nursing mothers. It appears that all antidepressants are secreted into the breast milk; however, the amount of medication to which the nursing child is exposed appears to be relatively small. We have the most information is available for fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), and the tricyclic antidepressants. In general, one should try to choose an antidepressant for which there are data to support its safety during breastfeeding. However, there are often situations where one may choose another antidepressant that has not been as well characterized. For instance, if a woman has not responded well to any of the above medications.

By MGH Center for Women's Mental Health|2015-07-21T10:41:36-04:00November 6th, 2002|Breastfeeding & Medications, Child Outcomes, Depressive Disorders|Comments Off

Reevaluating the Pros and Cons of Hormone Replacement Therapy

Each year, more than 1.3 million American women become menopausal in the U.S. The menopausal transition is marked by intense hormonal variability, and frequently accompanied by vasomotor symptoms (e.g., hot flashes, night sweats), sleep disturbance, and altered libido. In addition, as women become estrogen-deprived, they may also experience an increased risk for osteoporosis, cardiovascular disease, cognitive dysfunction, and depressive symptoms.

By MGH Center for Women's Mental Health|2015-07-20T11:48:35-04:00September 18th, 2002|Hormone Therapy, Menopausal Symptoms, Outcomes|Comments Off

Breastfeeding Boosts Intelligence

Over the years, various studies have demonstrated the many advantages of breastfeeding, findings that have led the American Academy of Pediatrics to recommend that all mothers breastfeed their children for the first year of the child's life. Several studies have also examined the relationship between breastfeeding and intellectual development in younger children and have demonstrated better cognitive functioning in children who were breastfed. The extent to which breastfeeding during infancy has an effect on later intellectual development has been more difficult to assess.

By MGH Center for Women's Mental Health|2015-07-20T11:05:48-04:00July 18th, 2002|Breastfeeding & Medications, Outcomes, Postpartum Psychiatric Disorders|Comments Off

Light Therapy for Depression During Pregnancy

Depression during pregnancy (antenatal depression) is relatively common, affecting about 10% of women. While there is a growing body of literature supporting the reproductive safety of certain antidepressants, our understanding of how these psychotropic medications affect the developing fetus remains incomplete. For this reason, antidepressants are typically avoided during pregnancy; thus, there is a clear need for effective non-pharmacologic treatments for women at high risk for antenatal depression.

By MGH Center for Women's Mental Health|2015-07-20T11:00:36-04:00June 23rd, 2002|Alternative & Complementary, Depressive Disorders, Psychiatric Disorders During Pregnancy, Treatment|Comments Off

Agnus Castus Fruit Extract as a Treatment for Premenstrual Syndrome

During the period before menstruation, many women report experiencing psychological and physical symptoms collectively referred to as premenstrual syndrome (PMS). The fruits, leaves and flowers of Vitex agnus castus (the Chaste Tree) have traditionally been used to relieve these symptoms. While the mode of action is not clear, the effects of the plant seem to mimic those of the corpus luteum, stimulating the production of lutenizing hormone, thereby increasing progesterone production. Schellenberg and colleagues recently studied the effects of agnus castus fruit in women with premenstrual syndrome.

By MGH Center for Women's Mental Health|2015-07-20T11:28:59-04:00May 20th, 2002|Alternative & Complementary, PMS & PMDD, Treatment|Comments Off

Depression and Preterm Labor

Although most people tend to think of pregnancy as a time of emotional well-being, depression is relatively common, affecting about 1 in 10 women. While there are obvious concerns related to the use of antidepressants during pregnancy and the effects of these medications on the developing fetus, less attention has focused on the impact of depression itself on the pregnancy. A recent study suggests that women with depression may be at greater risk for preterm labor.

By MGH Center for Women's Mental Health|2015-07-20T10:48:28-04:00April 30th, 2002|Depressive Disorders, Outcomes, Pregnancy Outcomes, Psychiatric Disorders During Pregnancy|Comments Off

Venlafaxine for Postpartum Depression

Postpartum depression (PPD) is relatively common, occurring in about 10 to 15% of women after delivery. Several reports have documented the efficacy of selective serotonin reuptake inhibitors (SSRIs) sertraline, fluoxetine, and fluvoxamine for the treatment of this disorder. In a recent report, Cohen and colleagues have demonstrated the efficacy of venlafaxine for the treatment of PPD.

By MGH Center for Women's Mental Health|2016-03-28T13:24:00-04:00February 20th, 2002|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off

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