Weekly Roundup for OCTOBER 5, 2018: Recent Publications in Women’s Mental Health
Two new studies explore the efficacy of non-pharmacologic treatments for depression during pregnancy. The first uses internet-derived cognitive behavioral therapy (Loughnan et al, 2018) in a group of pregnant women with anxiety and/or depression. The second is a randomized controlled trial of transcranial magnetic stimulation or TMS (Kim et al, 2018) for the treatment of antenatal depression. Ruta Nonacs, MD PhD A randomized controlled trial of 'MUMentum Pregnancy': Internet-delivered cognitive behavioral [...]
Using the EPDS During Pregnancy: What Exactly are We Screening For?
The American College of Obstetrics and Gynecology now recommends that women be screened for depression during pregnancy in addition to screening during the postpartum period. Because depressive symptoms during pregnancy have been associated with worse outcomes and are a robust predictor of postpartum depression, the identification of women with depression during pregnancy would help us to identify and treat women with symptoms during pregnancy and those who are at high risk [...]
Weekly Roundup for SEPTEMBER 28, 2018: Recent Publications in Women’s Mental Health
This week’s offering includes an article published in Pediatrics indicating that cannabis metabolites are found in the breast milk up to 6 days after the last use. A small prospective study from Wisner and colleagues looks at pregnancy outcomes in women with bipolar disorder. Ruta Nonacs, Md PhD Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk. Bertrand KA, Hanan NJ, Honerkamp-Smith G, Best BM, Chambers CD. Pediatrics. [...]
Brexanolone for Postpartum Depression: More Data, But Still Some Questions
In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression (PPD). SAGE-547, now called brexanolone, is an allosteric modulator of GABA-A receptors. We saw the preliminary results of the Sage Therapeutics Phase 3 Hummingbird Program earlier this year. Now we have the final set of results to consider. Participants were between the ages of 18 and 45 years and were less [...]
Options for treatment of bipolar disorder during pregnancy – ObGynNews
August 23, 2018 from ObGynNews The management of bipolar disorder during pregnancy is a critical clinical situation demanding great attention to issues such as reproductive safety of psychiatric medications used by women with bipolar disorder to maintain emotional well-being, compared with the established risk of relapse if patients stopped those medications. Treatment of bipolar disorder frequently includes mainstay treatment with mood stabilizers such as sodium valproate, lithium, lamotrigine, and second-generation atypical [...]
Weekly Roundup for SEPTEMBER 21, 2018: Recent Publications in Women’s Mental Health
Data on the most recent randomized controlled trial of brexanolone, a novel treatment for postpartum depression, were released. (We will review those in greater detail next week.) Guidelines for the treatment of perimenopausal depression were also published. Ruta Nonacs, Md PhD Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Meltzer-Brody S, Colquhoun H, Riesenberg R, Epperson CN, et al. Lancet Sept 2018. Intravenous administration of [...]