Mass General Hospital

Harvard Medical School

Welcome to the MGH Center for Women’s Mental Health

Welcome to the Massachusetts General Hospital Center for Women’s Mental Health, a perinatal and reproductive psychiatry information center.

This website provides a range of current information including discussion of new research findings in women’s mental health and how such investigations inform day-to-day clinical practice. Despite the growing number of studies being conducted in women’s health, the clinical implications of such work are frequently controversial, leaving patients with questions regarding the most appropriate path to follow. Providing these resources to patients and their doctors so that individual clinical decisions can be made in a thoughtful and collaborative fashion dovetails with the mission of our Center.

We hope you find this website informative and we welcome your comments.

The National Pregnancy Registry for Atypical Antipsychotics: All pregnant women ages 18-45 are eligible to enroll in the registry. We are currently seeking both controls and those being treated with one or more of the following atypical antipsychotics:
  • Abilify (aripiprazole)
  • Clozaril (clozapine)
  • Fanapt (iloperidone)
  • Geodon (ziprasidone)
  • Invega (paliperidone)
  • Latuda (lurasidone)
  • Risperdal (risperidone)
  • Saphris (asenapine)
  • Seroquel (quetiapine)
  • Zyprexa (olanzapine)
Register now by calling 1-866-961-2388 and help make the future better for many other women just like you. This study will involve 3 brief phone interviews over an 8-month period. The National Pregnancy Registry for Atypical Antipsychotics is dedicated to evaluating the safety of atypical antipsychotic medications that may be taken by women during pregnancy to treat a wide range of mood, anxiety, or psychiatric disorders. The primary goal of this Registry is to determine the frequency of major malformations, such as heart defects, cleft lip, or neural tube defects, in infants exposed to atypical antipsychotics during pregnancy. For more information, please call 1-866-961-2388.

The MGH Center for Women’s Mental Health
Perinatal and Reproductive Psychiatry Program
Simches Research Building
185 Cambridge St Suite 2200
Boston, MA 02114

To make an appointment:

Massachusetts General Hospital Clinical Program: (617) 724-7792

Latest News from our Blog

  • Pregnancy Loss May Affect Mood in Subsequent Pregnancies

    March 4, 2015


    Many women experience the loss of a pregnancy at some time in their lives. It is estimated that about 20% of all pregnancies end in miscarriage. In the United States, another 14% end in termination.1 The outcomes of pregnancies following a loss have been studied extensively, in order to understand whether those pregnancies will have ...

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  • You Asked: Is Duloxetine (Cymbalta) Safe To Use During Pregnancy?

    March 3, 2015


    We receive a fair number of questions on the use of duloxetine during pregnancy.  Duloxetine (sold in the United Sates under the brand name of Cymbalta) is a serotonin-norepinephrine reuptake inhibitor (SNRI) effective for major depressive disorder and generalized anxiety disorder (GAD). It has also been FDA-approved for the treatment of chronic musculoskeletal pain and ...

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  • Treating Depression During Pregnancy Prevents Postpartum Depression

    February 26, 2015


    This is a relatively small study but I think it underscores the importance of screening for and treating depression during pregnancy.  Previous studies have indicated that about 10% to 15% of women experience clinically significant depressive symptoms during pregnancy; however, depression that emerges during pregnancy often goes untreated. A recent naturalistic study from Turkey followed 78 ...

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  • Menopausal Vasomotor Symptoms Last Longer than Five Years for Most Women

    February 25, 2015


    Up to 80% of women experience vasomotor symptoms (VMS) as they transition into the menopause phase. While clinical guidelines suggest that VMS typically last from 6 months to 2 years, we often see women with VMS lasting for a much longer period of time. To more accurately assess the duration of VMS in perimenopausal women, ...

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  • New Recommendations Call for Iodine in All Prenatal Vitamins

    February 24, 2015


    In the developing baby, iodine is necessary for thyroid function and normal brain development. According to a recent Lancet study, even children born to women with mild-to-moderate iodine deficiency during pregnancy are at increased risk for lower IQ and reading ability (assessed at age 9). The most severe effects were observed among children born to ...

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  • Case Series: Mirtazapine (Remeron) in Pregnancy and Lactation

    February 23, 2015


    While we have adequate data to support the use of SSRI antidepressants during pregnancy, there is less data regarding other classes of antidepressants.  A new case series documents the outcomes of infants exposed to mirtazapine (Remeron).

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  • Infertility Treatment May Increase the Risk of Postpartum Depression

    February 18, 2015


    While many women complain of psychological distress during infertility treatment, it has been somewhat unclear if the anxiety and depression women may experience is related to having to undergo infertility treatment or to the hormonal agents that are used as part of the treatment, or a combination of the two.  Recent studies have attempted to identify ...

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  • Topiramate (Topamax) in Pregnancy May Affect Fetal Growth

    February 18, 2015


    This is a paper I missed from 2014, but I think this study adds some important information to the review we posted on topiramate a few weeks ago.

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  • Ethnic Minorities at Greater Risk of Depression during Pregnancy

    February 17, 2015

    While various studies have recently examined the prevalence of depression during pregnancy, few of these studies have examined how being an ethnic minority may influence the risk of antenatal depression.  A new study from Oslo, Norway suggests that certain ethnic minorities may have a higher risk. This was a population-based, prospective cohort of 749 pregnant women ...

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  • You Asked: Is Smoking While Breastfeeding Safe?

    February 11, 2015


    This is one of the most common questions sent in to our website.  Many women ask if it is safe to smoke while they are breastfeeding.  Smoking is relatively common during pregnancy, with about 10% of all women smoking at some point during their pregnancy. The rates are even higher among women with psychiatric illness.  ...

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