Mass General Hospital

Harvard Medical School

Welcome to the MGH Center for Women’s Mental Health


Welcome to the Massachusetts General Hospital Center for Women’s Mental Health, a perinatal and reproductive psychiatry information center. This website provides a range of current information including discussion of new research findings in women’s mental health and how such investigations inform day-to-day clinical practice. Despite the growing number of studies being conducted in women’s health, the clinical implications of such work are frequently controversial, leaving patients with questions regarding the most appropriate path to follow. Providing these resources to patients and their doctors so that individual clinical decisions can be made in a thoughtful and collaborative fashion dovetails with the mission of our Center.
The National Pregnancy Registry for Atypical Antipsychotics: All pregnant women ages 18-45 are eligible to enroll in the registry. We are currently seeking both controls and those being treated with one or more of the following atypical antipsychotics:
  • Abilify (aripiprazole)
  • Clozaril (clozapine)
  • Fanapt (iloperidone)
  • Geodon (ziprasidone)
  • Invega (paliperidone)
  • Latuda (lurasidone)
  • Risperdal (risperidone)
  • Saphris (asenapine)
  • Seroquel (quetiapine)
  • Zyprexa (olanzapine)
Register now by calling 1-866-961-2388 and help make the future better for many other women just like you. This study will involve 3 brief phone interviews over an 8-month period. The National Pregnancy Registry for Atypical Antipsychotics is dedicated to evaluating the safety of atypical antipsychotic medications that may be taken by women during pregnancy to treat a wide range of mood, anxiety, or psychiatric disorders. The primary goal of this Registry is to determine the frequency of major malformations, such as heart defects, cleft lip, or neural tube defects, in infants exposed to atypical antipsychotics during pregnancy. For more information, please call 1-866-961-2388.

The MGH Center for Women’s Mental Health

Perinatal and Reproductive Psychiatry Program

Simches Research Building

185 Cambridge St Suite 2200

Boston, MA 02114


To make an appointment:

Massachusetts General Hospital Clinical Program: (617) 724-7792

Latest News from our Blog

  • In Brief:  Improving Cognition in Schizophrenia by Modulating the Estrogen Receptor

    October 8, 2015


    This article in Psychiatric Times reviews some interesting research which suggests that drugs which modulate the estrogen receptor may improve cognitive functioning in patients with schizophrenia.  This is the first study to show that oral adjunctive treatment with raloxifene (120 mg per day) has beneficial effects on attention/processing speed and memory for both men and ...

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  • New Research from the CWMH: Reassuring Data from the National Pregnancy Registry of Atypical Antipsychotics

    October 7, 2015

    Baby Belly from Wikimedia Commons

    Despite the increasing use of the newer “atypical” or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data on the reproductive safety of these newer atypical agents.  In response to this deficit, the National Pregnancy Registry for Atypical ...

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  • Perinatal Depression is a Heritable Illness

    October 5, 2015

    Credit: Depressed Mother from Wikimedia Commons

    Perinatal depression is defined as depressive illness which emerges during pregnancy (antenatal depression) or following childbirth (postpartum depression).  We have limited information regarding the genetic basis of perinatal depression, but several studies suggest that the heritable component for perinatal depression may be greater than that observed for major depressive disorder which is unrelated to pregnancy. ...

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  • Is It Postpartum Depression or Postpartum Anxiety? What’s The Difference?

    September 30, 2015

    By Vera Kratochvil [Public domain], via Wikimedia Commons

    Meet Christine.  She is a married 30-year-old woman who just had her first baby about 3 weeks ago.  While the pregnancy went smoothly, the experience of labor and delivery was difficult.  After nearly 20 hours of labor, Christine had an emergency caesarean section.  The baby was healthy, but he had difficulty breastfeeding.  Christine was worried ...

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  • You Asked: Is There an Interaction Between Lamotrigine and Oral Contraceptives?

    September 29, 2015


      We get many questions about the interaction between lamotrigine (Lamictal) and oral contraceptives (OCs).  While many readers raise concerns that lamotrigine may decrease the effectiveness of oral contraceptives, the primary interaction is actually in the other direction.  In other words, oral contraceptives may decrease the effectiveness of lamotrigine.   Studies have shown that estrogens, which are ...

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  • Electroacupuncture Effective for Breast Cancer Treatment-Associated Hot Flashes

    September 22, 2015

    A recent study examined the effectiveness of electroacupuncture, in which small electric currents are applied to traditional acupuncture needles, in women with breast cancer treatment-associated hot flashes. 120 women with hot flashes were randomized to weekly electroacupuncture, once-daily gabapentin, sham acupuncture, or placebo for 8 weeks. Hot flashes were assessed using a daily self-reported hot flash ...

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