Mass General Hospital

Harvard Medical School

Welcome to the MGH Center for Women’s Mental Health


Welcome to the Massachusetts General Hospital Center for Women’s Mental Health, a perinatal and reproductive psychiatry information center. This website provides a range of current information including discussion of new research findings in women’s mental health and how such investigations inform day-to-day clinical practice. Despite the growing number of studies being conducted in women’s health, the clinical implications of such work are frequently controversial, leaving patients with questions regarding the most appropriate path to follow. Providing these resources to patients and their doctors so that individual clinical decisions can be made in a thoughtful and collaborative fashion dovetails with the mission of our Center.
The National Pregnancy Registry for Atypical Antipsychotics: All pregnant women ages 18-45 are eligible to enroll in the registry. We are currently seeking both controls and those being treated with one or more of the following atypical antipsychotics:
  • Abilify (aripiprazole)
  • Clozaril (clozapine)
  • Fanapt (iloperidone)
  • Geodon (ziprasidone)
  • Invega (paliperidone)
  • Latuda (lurasidone)
  • Risperdal (risperidone)
  • Saphris (asenapine)
  • Seroquel (quetiapine)
  • Zyprexa (olanzapine)
Register now by calling 1-866-961-2388 and help make the future better for many other women just like you. This study will involve 3 brief phone interviews over an 8-month period. The National Pregnancy Registry for Atypical Antipsychotics is dedicated to evaluating the safety of atypical antipsychotic medications that may be taken by women during pregnancy to treat a wide range of mood, anxiety, or psychiatric disorders. The primary goal of this Registry is to determine the frequency of major malformations, such as heart defects, cleft lip, or neural tube defects, in infants exposed to atypical antipsychotics during pregnancy. For more information, please call 1-866-961-2388.

The MGH Center for Women’s Mental Health

Perinatal and Reproductive Psychiatry Program

Simches Research Building

185 Cambridge St Suite 2200

Boston, MA 02114


To make an appointment:

Massachusetts General Hospital Clinical Program: (617) 724-7792

Latest News from our Blog

  • In Brief: Venlafaxine as Effective as Low-Dose Estradiol for Menopausal Sleep Symptoms

    August 31, 2015


    Which treatment is best for managing menopausal sleep problems? We tend to think of estrogen replacement therapy as being the best option for all menopausal symptoms; however, there are other options for managing menopausal symptoms, including serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors, and gabapentin. A recent study compares low-dose estradiol and low-dose venlafaxine for the ...

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  • Telephone-Based CBT for Postpartum Depression

    August 25, 2015

    Credit: Depressed Mother from Wikimedia Commons

    Cognitive-behavioral therapy (CBT) is an effective treatment for mood and anxiety disorders and has been shown to be effective for the treatment of postpartum depression (PPD).  However, not all women have access to CBT-savvy therapists.  In addition, it is often difficult for new mothers to travel outside of the home for regular appointments.  A recent ...

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  • Many Pregnant Women Unaware of the Risks of Electronic Cigarettes

    August 24, 2015


    More and more people are using electronic cigarettes.  While e-cigarettes are often touted as being safer than tobacco-containing cigarettes, there is fierce debate among experts as to whether this is actually the case.  There is also no evidence that e-cigarettes facilitate smoking cessation. A recent study suggests that many pregnant women — more than 40% of ...

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  • Proving the Estrogen Withdrawal Hypothesis of Perimenopausal Depression

    August 18, 2015

    Photo by Christoph Lehmann

    Because women appear to be at increased risk for new onset and recurrent depression as they transition into the menopause, it has been hypothesized that declining ovarian function — or estrogen “withdrawal” — may trigger depressive symptoms in some women.  While this is a very reasonable and totally plausible hypothesis, no studies have formally tested ...

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  • Pregnancy Brain?  Or is it Depression?

    August 17, 2015

    Credit: Hugrekk via flickr

    Many pregnant women complain of “pregnancy brain”.  They describe that they feel less sharp than usual and often complain of bouts of forgetfulness.  Is it because they are distracted by thinking about and planning for the arrival of the new baby?  Is it the hormones? Is it sleep deprivation? A new study suggests that depression may ...

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  • Research Study: Vortioxetine for Perimenopausal and Postmenopausal Women

    August 14, 2015

    Photo by Christoph Lehmann

    The menopausal transition is a difficult time for many women.  There is an increased risk of depressive episodes during this transition in the reproductive lifecycle, and the majority of women will experience symptoms related to perimenopause (such as hot flashes, sleep disturbance, and cognitive complaints). Vortioxetine (brand name Brintellix) is a novel antidepressant that was recently ...

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