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Archive | Psychiatric Medicationss Before Pregnancy

Use of ADHD Medications Increasing in Women of Reproductive Age

  According to a report published by the CDC in Morbidity and Mortality Weekly Report (MMWR), the use of stimulant medications for the treatment of attention-deficit/hyperactivity disorder (ADHD)  by reproductive-age women is on the rise.   Researchers analyzed data from the Truven Health MarketScan Commercial Database (2003–2015) to estimate the percentage of women aged 15–44 […]

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France Bans the Use of Valproic Acid in Some Women of Childbearing Age

There have long been concerns regarding the safety of the anticonvulsant valproate (Depakote) during pregnancy.  Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid in women of childbearing age because of the various risks associated with prenatal exposure.  Raising similar concerns in 2014, the European […]

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Credit: Pregnant Woman from Wikimedia Commons

Why Are We Still Using Valproic Acid (Depakote) in Women of Childbearing Age?

  There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy.  First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as an increased risk of other malformations affecting the heart, limbs, and genitals. Prenatal exposure to valproate may also result in […]

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New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

Despite the increasing use of the newer “atypical” or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data on the reproductive safety of these newer atypical agents. In response to this deficit, the National Pregnancy Registry for Atypical […]

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November 2015 Roundup: Recent Publications in Reproductive Psychiatry

It has been another busy month! Ruta Nonacs, MD PhD Antidepressants, pregnancy, and stigma: how we are failing mothers and babies. Osborne LM, Payne J. J Nerv Ment Dis. 2015 Mar;203(3):164-6. Do anxiety symptoms predict major depressive disorder in midlife women? The Study of Women’s Health Across the Nation (SWAN) Mental Health Study (MHS). Kravitz HM, Schott LL, Joffe H, […]

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Topiramate and Pregnancy: More on Risk of Major Malformations

Topiramate (TPM, marketed as Topamax) is an antiepileptic drug which is also used for migraine prophylaxis, weight loss, and, less commonly, as a mood stabilizer.  Over the last few years we have seen several studies suggesting an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy.  A recent […]

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