|The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study.
Edvinsson Å, Hellgren C, Kunovac Kallak T, Åkerud H, Skalkidou A, Stener-Victorin E, Fornes R, Spigset O, Lager S, Olivier J, Sundström-Poromaa I.
BMC Pregnancy Childbirth. 2019 Dec 5;19(1):479. Free article.
This study compared placental gene and protein expression in healthy women, women with untreated antenatal depression and women on antidepressant treatment during pregnancy. Nominally significant findings were noted for HTR1A (which codes for G-protein coupled receptor for serotonin)and NPY2R (which codes for a neuropeptide Y receptor), where women with untreated depression displayed higher gene expression than healthy controls (p < 0.05), whereas women on antidepressant treatment had similar expression as healthy controls.
Universal prevention of distress aimed at pregnant women: a systematic review and meta-analysis of psychological interventions.
Missler M, Donker T, Beijers R, Ciharova M, Moyse C, de Vries R, Denissen J, van Straten A. BMC Pregnancy Childbirth. 2021 Apr 1;21(1):276. Free article.
Overall, ten studies included depression as an outcome measure, five studies included stress, and four studies anxiety. There was a moderate effect of preventive interventions implemented during pregnancy on the combined measure of maternal distress (d = .52), on depressive symptoms (d = .50), and on stress (d = .52). The effect on anxiety (d = .30) was smaller.
I’ll catch you when you fall: Social safety nets and housing instability in IPV-exposed pregnant women.
Miller-Graff L, et al. J Affect Disord, May 2021.
Social support was directly related to lower levels of depressed mood and posttraumatic stress in IPV-exposed women.