Every week we review the most recent publications in women’s mental health, covering topics related to premenstrual symptoms, perinatal mood and anxiety disorders, use of medications in pregnant and breastfeeding women, perinatal substance use, and menopausal mental health. 

For more detailed descriptions of many of these topics, you can sign up to receive our weekly CWMH NEWSLETTER which comes out every Thursday.  

And don’t forget to visit ESSENTIAL READS – a curated selection of up-to-date and clinically relevant articles in women’s mental health.

Ruta Nonacs, MD PhD


A randomized, double-blind study on efficacy and safety of sepranolone in premenstrual dysphoric disorder.

Bäckström T, Ekberg K, Hirschberg AL, Bixo M, Epperson CN, Briggs P, Panay N, O’Brien S.  Psychoneuroendocrinology. 2021 Sep 23;133:105426.

In women with PMDD, subcutaneous the neuroactive steroid sepranolone led to improvements in PMDD symptoms, impairment, and distress.  Sepranolone was well tolerated, and no safety concerns were identified.



No articles this week



Patterns of psychiatric admission in Australian pregnant and childbearing women.

Austin MP, Ambrosi TL, Reilly N, Croft M, Hutchinson J, Donnolley N, Mihalopoulos C, Chatterton ML, Chambers GM, Sullivan E, Knox C, Xu F, Highet N, Morgan VA.  Soc Psychiatry Psychiatr Epidemiol. 2021 Jul 22.

The entire perinatal period is a time of increased risk for admission across the range of psychiatric disorders, compared to other times in a woman’s childbearing years. Reduced admission rate and length of stay for socially disadvantaged women suggest lack of equity of access.


The first 20?weeks of pregnancy is a high-risk period for eating disorder relapse.

Sollid C, Clausen L, Maimburg RD.  Int J Eat Disord. 2021 Sep 28.

In this cohort of women with eating disorders, 25% relapsed. Twenty women relapsed within the first 20 weeks of pregnancy and eight in the early weeks postpartum. Severe postpartum depression symptoms (33%) were frequent in women with ED relapse; hyperemesis gravidarum (30%) was frequently present independent of the woman’s relapse status.


Implementation of perinatal collaborative care: a health services approach to perinatal depression care.

Miller ES, Jensen R, Hoffman MC, Osborne LM, McEvoy K, Grote N, Moses-Kolko EL.

Prim Health Care Res Dev. 2020 Sep 10;21:e30. Free article.



No articles this week



The development of the postpartum mobile support application and the effect of the application on mothers’ anxiety and depression symptoms.

Koçak V, Ege E, ?yisoy MS.  Arch Psychiatr Nurs. 2021 Oct;35(5):441-449. 

The depression symptoms of mothers using the postpartum mobile support application was lower than that of the mothers in the control group; however, it was found that the application was not adequate alone to decrease anxiety levels and depression symptoms (p > 0.05).


Maternal post-traumatic stress and depression symptoms and outcomes after NICU discharge in a low-income sample: a cross-sectional study.

Gateau K, Song A, Vanderbilt DL, Gong C, Friedlich P, Kipke M, Lakshmanan A.  BMC Pregnancy Childbirth. 2021 Jan 12;21(1):48.Free article.

After having an infant in the NICU, more than one-third of the mothers in this sample screened positively for post-traumatic symptoms  and depression symptoms.


Prenatal insomnia and childbirth-related PTSD symptoms: A prospective population-based cohort study.

Deforges C, Noël Y, Eberhard-Gran M, Garthus-Niegel S, Horsch A.  J Affect Disord. 2021 Aug 24;295:305-315. Free article.

Insomnia symptoms during pregnancy  may impair the ability to cope with a difficult birth experience and contribute to postpartum insomnia, a risk factor for CB-PTSD. 


Postpartum psychosis: a diagnosis for the DSMV.

Spinelli M.  Arch Womens Ment Health. 2021 Sep 8. 

This work describes a proposal to the DSM-V committee in 2020 for inclusion of PPP as a unique diagnosis based on the cognitive disorganization that accompanies psychotic symptoms. The proposal for inclusion provides the required criteria such as a rationale for the proposed change and evidence that PPP is distinct from other disorders. 



No articles this week



Low barrier perinatal psychiatric care for patients with substance use disorder: meeting patients across the perinatal continuum where they are.

Raffi ER, Gray J, Conteh N, Kane M, Cohen LS, Schiff DM.  Int Rev Psychiatry. 2021 Aug 18:1-10.


Association of Timing and Duration of Prenatal Analgesic Opioid Exposure With Attention-Deficit/Hyperactivity Disorder in Children.

Trønnes JN, Lupattelli A, Handal M, Skurtveit S, Ystrom E, Nordeng H.  JAMA Netw Open. 2021 Sep 1;4(9):e2124324. Free article.

In a cohort of children at 5 years of age, this study found a slightly elevated risk of ADHD diagnosis after prenatal opioid exposure for 5 or more weeks compared with exposure for 4 weeks or less. This result may be driven by longer duration of use; however, the role of residual or unmeasured confounding cannot be excluded. 



Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.

Roffman JL, Sipahi ED, Dowling KF, Hughes DE, Hopkinson CE, Lee H, Eryilmaz H, Cohen LS, Gilman J, Doyle AE, Dunn EC.  PLoS One. 2021 Apr 28;16(4):e0250235. Free article.

Exposures 6 different adverse events during pregnancy were associated with  significant albeit small increases in measures of psychopathology in the offspring at ages 9-10, as assessed using the Child Behavior Checklist (CBCL) total score: unplanned pregnancy; maternal alcohol, marijuana, and tobacco use early in pregnancy; pregnancy complications; and birth complications.


Maternal and paternal depression and child mental health trajectories: evidence from the Avon Longitudinal Study of Parents and Children.

Rajyaguru P, Kwong ASF, Braithwaite E, Pearson RM.  BJPsych Open. 2021 Sep 24;7(5):e166. 

Exposure to maternal depression both during pregnancy and the postpartum period is strongly associated with greater offspring trajectories of depressive symptoms.


Maternal perinatal anxiety and neural responding to infant affective signals: Insights, challenges, and a road map for neuroimaging research.

Yatziv T, Vancor EA, Bunderson M, Rutherford HJV.  Neurosci Biobehav Rev. 2021 Sep 24;131:387-399. 



No articles this week



No articles this week



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