|High worry in pregnancy predicts postpartum depression.
Osborne LM, Voegtline K, Standeven LR, Sundel B, Pangtey M, Hantsoo L, Payne JL.
J Affect Disord. 2021 Nov 1;294:701-706.
Women with a history or current diagnosis of major depressive disorder (MDD) or generalized anxiety disorder (GAD) were more likely to experience high antenatal worry. High antenatal worry was the only significant predictor of postpartum depressive symptoms, with an odds ratio (OR) of 3.91 (95% CI 1.44-10.65).
Long-term outcome of postpartum psychosis: a prospective clinical cohort study in 106 women.
Rommel AS, Molenaar NM, Gilden J, Kushner SA, Westerbeek NJ, Kamperman AM, Bergink V.
Int J Bipolar Disord. 2021 Oct 28;9(1):31.
Over two thirds of the women included in this study did not have major psychiatric episodes outside of the postpartum period during follow-up. The overall recurrence rate of mood/psychotic episodes outside the postpartum period was ~ 32%.
Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores.
Di Florio A, Mei Kay Yang J, Crawford K, Bergink V, Leonenko G, Pardiñas AF, Escott-Price V, Gordon-Smith K, Owen MJ, Craddock N, Jones L, O’Donovan M, Jones I.
Lancet Psychiatry. 2021 Oct 26:S2215-0366(21)00253-4.
This study supports the recognition of first-onset post-partum psychosis as a separate nosological entity within the bipolar disorder spectrum
Bipolar episodes after reproductive events in women with bipolar I disorder, A study of 919 pregnancies.
Gilden J, Poels EMP, Lambrichts S, Vreeker A, Boks MPM, Ophoff RA, Kahn RS, Kamperman AM, Bergink V.
J Affect Disord. 2021 Dec 1;295:72-7.
Episode risk was 5.2% during pregnancy, and 30.1% in the postpartum period, with a peak in the early postpartum period. Risk of an episode was highest after live birth (34.4%), and lower after miscarriage (15.2%) and induced abortion (27.8%).