Every week we review the most recent publications in women’s mental health, covering topics related to premenstrual symptoms, perinatal mood and anxiety disorders, use of medications in pregnant and breastfeeding women, perinatal substance use, and menopausal mental health.

For more detailed descriptions of many of these topics, you can sign up to receive our weekly CWMH NEWSLETTER which comes out every Thursday.

Ruta Nonacs, MD PhD

 

PMS AND PMDD

No articles this week

INFERTILITY AND MENTAL HEALTH

No articles this week

PSYCHIATRIC ILLNESS DURING PREGNANCY

Should Women Stop ADHD Meds During Pregnancy?

Study reviewed on MedPage: Continuing dexamphetamine for attention deficit-hyperactivity disorder (ADHD) during pregnancy was not associated with a higher likelihood of adverse maternal and neonatal outcomes compared with stopping the medication during pregnancy.

MEDICATIONS AND PREGNANCY

Where are the data to assess the safety of paternal drug exposure? A systematic review of secondary databases: A contribution from IMI concePTION – PubMed

Most studies assessing the safety of parental drug exposures during pregnancy and around the time of conception describe the effects of maternal exposure. Few studies have been completed on paternal medication exposures and pregnancy outcomes, despite the availability of secondary databases that contain data necessary to link fathers to infants. 

Impact of genetic, sociodemographic, and clinical features on antidepressant treatment trajectories in the perinatal period – PubMed

Continuation of antidepressants during pregnancy is influenced by the clinical severity of the disease rather than genetic predisposition as measured by PGSs.

Risks associated with antidepressants in patients with hypertension during pregnancy: a retrospective cohort study – PubMed

This study found no additional maternal or neonatal risks associated with using antidepressants prescribed to women with hypertension disorders during pregnancy.

Association between antidepressant use during pregnancy and miscarriage: a systematic review and meta-analysis – PubMed

After accounting for maternal depression, there is little evidence of any association between antidepressant use during pregnancy and miscarriage. Instead, the results indicate the biasing impact of confounding by indication.

Prescription Opioid Exposure During Pregnancy Elevates Preterm Delivery Risk

Study reviewed in Psychiatry Advisor: Prescription opioid exposure during pregnancy is positively associated with increased odds of spontaneous preterm birth in a dose-dependent manner. These findings, published in JAMA Network Open, emphasize the importance of prescribing the lowest necessary dose of opioids for pain management during pregnancy.

 

POSTPARTUM PSYCHIATRIC ILLNESS

Indirect comparisons of relative efficacy estimates of zuranolone and selective serotonin reuptake inhibitors for postpartum depression 

Analysis showed zuranolone-treated patients with PPD experienced greater symptom improvement than SSRI-treated patients from Day 15 onward, with largest mean difference at Day 45. Adjusting for differences between placebo arms, zuranolone may be associated with greater PPD symptom improvement (measured by EPDS) vs. SSRIs.

MEDICATIONS AND BREASTFEEDING

No articles this week

PERINATAL SUBSTANCE USE

Pregnancy and Postpartum Drug Overdose Deaths in the US Before and During the COVID-19 Pandemic

From 2018 to 2021, the mortality ratio more than tripled among pregnant and postpartum women aged 35 to 44 years, consistent with increases in overdose mortality across US populations. 

Substance Use in Pregnancy Ups Risk of ADHD For Child

Study reviewed in Psychiatric News: Children whose mothers used alcohol, tobacco, and/or cannabis while pregnant were two to four times more likely to have ADHD symptoms than those whose mothers did not use these substances.

Prenatal Tobacco Use Tied to Impaired Language, Memory Development in Offspring

Study Reviewed in Psychiatry Advisor: Relative to controls, children exposed to MTDP had smaller cortical areas and volumes, as well as worse language and memory development scores.

MATERNAL MENTAL HEALTH AND CHILD OUTCOMES

No articles this week

MENOPAUSE AND MENTAL HEALTH

More optimistic postmenopausal women tended to have better physical functioning marked by greater grip strength and more chair stand completions, a longitudinal cohort study showed. (JAMA Psychiatry).

 

Psychosocial Interventions Improve Depression and Anxiety During Menopause

Study reviewed in Psychiatry Advisor: Psychosocial interventions of cognitive behavioral therapy (CBT) and mindfulness-based interventions (MBI) improve depression and anxiety during menopause, according to systematic review and meta-analysis findings published in the Journal of Affective Disorders. These interventions also improved cognition and quality of life for individuals experiencing menopause.

OTHER TOPICS IN WOMEN’S MENTAL HEALTH

Pregnancy advances your ‘biological’ age — but giving birth turns it back

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