At the top of the list is an article about brexanolone, a derivative of allopregnanolone, which in a small pilot study was effective for the treatment of postpartum depression. Also interesting are two articles which discuss perinatal anxiety (from Dennis and colleagues); both of these studies indicate that anxiety is just as common as depression during the perinatal period.
Ruta Nonacs, MD PhD
Kanes SJ, Colquhoun H, Doherty J, Raines S, Hoffmann E, Rubinow DR, Meltzer-Brody S.
Hum Psychopharmacol. 2017 Mar;32(2).
Brexanolone (formerly SAGE-547), is an injectable allopregnanolone formulation. In an open-label study, brexanolone was effective for the treatment of severe PPD.
Dennis CL, Brown HK, Falah-Hassani K, Marini FC, Vigod SN. J Affect Disord. 2017 Apr 15;213:131-137.
The prevalence of sustained postpartum anxiety was 12.6%. Perceived stress at one week postpartum increased risk for anxiety, whereas partners support decreased risk.
Dennis CL, Falah-Hassani K, Shiri R. Br J Psychiatry. 2017 Mar 16.
The prevalence for self-reported anxiety symptoms was 18.2% in the first trimester, 19.1% in the second trimester and 24.6% in the third trimester. Postnatally, the prevalence for anxiety symptoms was high initially but overall between 1 to 24 weeks was 15.0%.
Shanmugan S, Loughead J, Cao W, Sammel MD, Satterthwaite TD, Ruparel K, Gur RC, Epperson CN. Neuropsychopharmacology. 2017 Mar 21.
Shanmugan S, Loughead J, Nanga RP, Elliott M, Hariharan H, Appleby D, Kim D, Ruparel K, Reddy R, Brown TE, Epperson CN. Neuropsychopharmacology. 2017 Jan;42(2):437-445.
Ecklund-Flores L, Myers MM, Monk C, Perez A, Odendaal HJ, Fifer WP. Dev Psychobiol. 2017 Apr;59(3):314-323.
Among 227 pregnant women, depressed women who carry to term had significantly higher heart rates, lower heart rate variability, and gave birth to heavier babies than those of pregnant women who were not depressed.
Zhang H, Su Q, Yao D, Wang S, Dang S, Ding D, Zhu Z, Shao S, Li H. J Affect Disord. 2017 Mar 18;215:274-280.
The newborns of mothers exposed to maternal perinatal depressive symptoms displayed reduced newborn social interactive behaviors, and were accompanied by lower maternal prolactin levels, as well as increased maternal and neonatal cortisol levels.
Taka-Eilola Née Riekki T, Miettunen J, Mäki P. Eur Psychiatry. 2016 Dec 28;42:36-43.
There were no statistically significant differences in schizotypal and affective scales between offspring with and without antenatally depressed mothers.
Comasco E, Sylvén SM, Papadopoulos FC, Sundström-Poromaa I, Oreland L, Skalkidou A.
Psychiatr Genet. 2011 Feb;21(1):19-28.
Genetic variations in the monoaminergic neurotransmitter system, together with environmental stressors, contribute to the development of PPD symptoms. The COMT-Val158Met variant was significantly associated with PPD symptoms at 6 weeks, but not at 6 months postpartum. Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LPR risk variants were associated with PPD symptoms, whereas in the absence of previous psychiatric contact only maternity stressors were related to PPD symptoms.
Wynter K, Tran TD, Rowe H, Fisher J. J Affect Disord. 2017 Mar 14;215:56-61.
Talati A, Wickramaratne PJ, Wesselhoeft R, Weissman MM. Psychiatry Res. 2017 Mar 8;252:346-352.
Prenatal tobacco exposure was associated with 0.7lb (9%) lower birthweight, increased rates of disruptive behavior disorders (males: OR=2.66), substance use disorders (females: OR=2.23), and decreased rates of mood disorders (males: OR=0.42).
Paramsothy P, Harlow SD, Nan B, Greendale GA, Santoro N, Crawford SL, Gold EB, Tepper PG, Randolph JF Jr. Menopause. 2017 Feb;24(2):142-149.
The adjusted median duration of the menopause transition ranged from 4.37 years among the oldest age-at-onset quartile to 8.57 years among the youngest age-at-onset quartile. Cigarette smoking was associated with an earlier onset and a shorter duration. African American women had a longer duration than white women. Body mass index was associated with a later onset but did not affect its duration.