Every week we review the most recent publications in women’s mental health, covering topics related to premenstrual symptoms, perinatal mood and anxiety disorders, use of medications in pregnant and breastfeeding women, perinatal substance use, and menopausal mental health. 

For more detailed descriptions of many of these topics, you can sign up to receive our weekly CWMH NEWSLETTER which comes out every Thursday.  

And don’t forget to visit ESSENTIAL READS – a curated selection of up-to-date and clinically relevant articles in women’s mental health.

Ruta Nonacs, MD PhD



The Influence of Depression on Biased Diagnosis of Premenstrual Syndrome and Premenstrual Dysphoric Disorder by the PSST Inventory.

?liwerski A, Kosza?kowska K. Life (Basel). 2021 Nov 22;11(11):1278.

While diagnosing premenstrual disorders, clinicians should be aware that a retrospective diagnosis with PSST can be more sensitive to mood disorders and cycle phases than a prospective diagnosis with a daily symptoms calendar.


No articles this week


Randomized controlled trial of digital cognitive behavior therapy for prenatal insomnia symptoms: Effects on postpartum insomnia and mental health.

Felder JN, Epel ES, Neuhaus J, Krystal AD, Prather AA. Sleep. 2021 Nov 27:zsab280

Digital CBT-I participants did not experience significantly greater improvements in insomnia symptom severity relative to standard care participants, but they did experience higher rates of insomnia remission and lower rates of insomnia caseness at six months postpartum.

Does One Treatment Fit All? Effectiveness of a Multicomponent Cognitive Behavioral Therapy Program in Data-Driven Subtypes of Perinatal Depression.

Waqas A, Rahman A. Front Psychiatry. 2021 Nov 17;12:736790. Free article.

The Thinking Healthy Programme was found to be effective in reducing severity of depressive symptoms and disability across the four subtypes of perinatal depression: mixed anxiety-depression, somatic depression, mild depression, and atypical depression.

Women’s experiences and perceptions of anxiety and stress during the perinatal period: a systematic review and qualitative evidence synthesis.

McCarthy M, Houghton C, Matvienko-Sikar K. BMC Pregnancy Childbirth. 2021 Dec 6;21(1):811. Free article.

Noh Y, Choe SA, Kim WJ, Shin JY. Discontinuation and re-initiation of antidepressants during pregnancy: A nationwide cohort study. J Affect Disord. 2022;298(Pt A):500-507. Among 5207 pregnancies, 4954 (95.1%) discontinued antidepressants during pregnancy, which included 4657 (89.4%) in the first trimester, 1810 (38.9%) of whom re-initiated them during pregnancy or postpartum period.


Association between antidepressant use in pregnancy and gestational diabetes mellitus: Results from the Norwegian Mother, Father and Child Cohort Study.

Lupattelli A, Barone-Adesi F, Nordeng H. Pharmacoepidemiol Drug Saf. 2021 Nov 24.

Overall, 84 (1.3%) of the pregnancies developed GDM. Relative to non-medicated pregnancies, the risk of GDM was slightly lower in pregnancies exposed to antidepressants with low H1 receptor affinity (1.3% vs 1.1%), but more elevated in those exposed to antidepressants with higher H1 receptor affinity (3.9%).

Long-Acting Injectable Antipsychotic Medications in Pregnancy: A Review.

O’Sullivan DL, Byatt N, Dossett EC. J Acad Consult Liaison Psychiatry. 2021 Aug 27:S2667-2960(21)00151-8.

There is little research specifically examining the use of LAIs in pregnancy.


Randomized trial examining the effect of exercise and wellness interventions on preventing postpartum depression and perceived stress.

Lewis BA, Schuver K, Dunsiger S, Samson L, Frayeh AL, Terrell CA, Ciccolo JT, Fischer J, Avery MD. BMC Pregnancy Childbirth. 2021 Nov 22;21(1):785.

The wellness intervention was efficacious for preventing symptoms of depression; however, postpartum depression that met the diagnostic criteria was surprisingly low in all conditions among this at-risk sample of postpartum women.

Maternal Obsessive-Compulsive Symptoms and Infant Feeding Practices.

Phillips WL, Keim SA, Crerand CE, Jackson JL. Breastfeed Med. 2021 Dec 3. d

Of 232 participants, 32 (14%) had clinically elevated OC symptoms. These symptoms were associated with more breastfeeding problems.

Postpartum anhedonia: Emergent patterns in bipolar and unipolar depression.

Gollan JK, Yang A, Ciolino JD, Sit D, Wisner KL. Psychiatry Res. 2021 Dec;306:114274.

Across time, among those who reported postpartum anhedonia, twice as many women had the diagnoses of bipolar depression relative to unipolar depression (65.03% versus 39.47%, respectively). Moreover, the rate and stability of anhedonia was higher in women with bipolar relative to unipolar depression. Across groups, anhedonia was associated with significantly higher depressive symptom severity. Anhedonia is a more stable and frequent symptom in women with postpartum bipolar relative to unipolar depressive disorder.

Depression, anxiety, PTSD, and OCD after stillbirth: a systematic review.

Westby CL, Erlandsen AR, Nilsen SA, Visted E, Thimm JC. BMC Pregnancy Childbirth. 2021 Nov 18;21(1):782. Free article.

Parents who experience stillbirth have a considerably higher risk of reporting symptoms of depression, anxiety, and PTSD compared with parents with live births.

A promising new model of care for postpartum depression: A randomised controlled trial of a brief home visitation program conducted in Houston, Texas, USA.

Van Horne BS, Nong YH, Cain CM, Sampson M, Greeley CS, Puryear L. Health Soc Care Community. 2021 Dec 5.

A short-term home visitation program by a social worker (PST4PPD) appears to be a promising treatment option for postpartum women with mild to moderate PPD symptoms.


No articles this week


No articles this week


Major depression as a predictor of the intergenerational transmission of attachment security: Findings from a pregnancy cohort study.

Galbally M, Watson SJ, Tharner A, Luijk M, Blankley G, MacMillan KK, Power J, Lewis AJ. Aust N Z J Psychiatry. 2021 Nov 29:48674211060749.

Associations of parental mental disorders and age with childhood mental disorders: a population-based cohort study with four million offspring.

Liang CS, Bai YM, Hsu JW, Huang KL, Ko NY, Yeh TC, Chu HT, Tsai SJ, Chen TJ, Chen MH. Eur Child Adolesc Psychiatry. 2021 Nov 21.

Both paternal and maternal mental disorders were associated with higher risks of within-disorder transmission for ADHD, autism spectrum disorder, major depressive disorder, and bipolar disorder (range of OR: 2.64 to 30.41).


No articles this week


No articles this week

Related Posts