Sometimes a weekly roundup turns into a monthly roundup.  Sorry about that.  From  the PACT Consortium, we have a study defining distinct subtypes of perinatal depression which differ in terms of severity and timing of onset.

Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium.

Putnam KT, Wilcox M, Robertson-Blackmore E, Sharkey K, Bergink V, Munk-Olsen T, Deligiannidis KM, Payne J, Altemus M, Newport J, Apter G, Devouche E, Viktorin A, Magnusson P, Penninx B, Buist A, Bilszta J, O’Hara M, Stuart S, Brock R, Roza S, Tiemeier H, Guille C, Epperson CN, Kim D, Schmidt P, Martinez P, Di Florio A, Wisner KL, Stowe Z, Jones I, Sullivan PF, Rubinow D, Wildenhaus K, Meltzer-Brody S; Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium.  Lancet Psychiatry. 2017 Jun;4(6):477-485.

Using data for 663 women, this study found evidence for five distinct subtypes of perinatal depression: severe anxious depression, moderate anxious depression, anxious anhedonia, pure anhedonia, and resolved depression. These subtypes have clear differences in symptom quality and time of onset.

Polyunsaturated fatty acids and inflammatory markers in major depressive episodes during pregnancy.

Chang JP, Lin CY, Lin PY, Shih YH, Chiu TH, Ho M, Yang HT, Huang SY, Ga?ecki P, Su KP.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 May 20. [Epub ahead of print]

Women with depression during pregnancy had significantly lower levels of total omega-3 fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) but a higher omega-6 to omega-3 ratio.  Levels of the inflammatory marker, tumor necrosis factor alpha (TNF-?), were also higher in the women with prenatal depression.  

One-Year Developmental Outcomes for Infants of Mothers With Bipolar Disorder.

Santucci AK, Singer LT, Wisniewski SR, Luther JF, Eng HF, Sit DK, Wisner KL.  J Clin Psychiatry. 2017 Jan 3.

In a longitudinal study, infant outcomes were assessed in 27 women with bipolar disorder who received  no treatment with psychotropic medications during pregnancy (BD-) and 54 women with bipolar disorder who received psychotropic medication during pregnancy (BD+).  The control group consisted of 116 women with no exposures to either bipolar disorder or psychotropic medication.  There were no differences in overall scores on tests of psychomotor, cognitive and behavioral development.  Children in the BD+ group differed with regard to quality of motor functioning at 1 year. However, the majority of infants were within normal limits.  

Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy.

Rosa CE, Soares JC, Figueiredo FP, Cavalli RC, Barbieri MA, Schaufelberger MS, Salmon CEG, Del-Ben CM, Santos AC.  Psychiatry Res. 2017 Apr 26;265:18-25.

Women with PPD had dysfunction in the glutaminergic neurotransmitter system similar to that observed in other types of depression.

Living with parents or with parents-in-law and postpartum depression: A preliminary investigation in China.

Wang YY, Li H, Wang YJ, Wang H, Zhang YR, Gong L, Ma J, Wang Y, Wang MZ, Qiu SX, Yuan SX.  J Affect Disord. 2017 Apr 25;218:335-338.

In this study from China, women living with their parents-in-law had higher risk of postpartum depression after adjustment for potential confounders (OR=2.48). Women living with their own parents experienced the same risk for PPD as women living only with their husbands.

Benefits of preparing for childbirth with mindfulness training: a randomized controlled trial with active comparison.

Duncan LG, Cohn MA, Chao MT, Cook JG, Riccobono J, Bardacke N.  BMC Pregnancy Childbirth. 2017 May 12;17(1):140.  Free Article

In a small randomized clinical trial, mindfulness-based childbirth education improved women’s  psychological functioning (and reduced depressive symptoms) in comparison to standard childbirth education.

Psychotropic Drug Use before, during, and after Pregnancy: A Population-Based Study in a Canadian Cohort (2001-2013).

Leong C, Raymond C, Château D, Dahl M, Alessi-Severini S, Falk J, Bugden S, Katz A.  Can J Psychiatry. 2017 Jan 1.

A psychotropic drug was used before, during, or after pregnancy in 41,923 of 224,762 pregnancies. From 2001 to 2013, psychotropic use increased 1.5-fold from 11.1% to 16.2% in the 3-12 months before pregnancy, 1.8-fold from 3.3% to 6.0% during pregnancy, and 1.5-fold from 6.2% to 9.5% during the 3 months postpartum. Among the 13,579 women who received at least 1 psychotropic agent in the 3 months prior to pregnancy, 38.5% stopped the agent prior to pregnancy and only 10.3% continued use throughout pregnancy.

Risk of postpartum episodes in women with bipolar disorder after lamotrigine or lithium use during pregnancy: A population-based cohort study.

Wesseloo R, Liu X, Clark CT, Kushner SA, Munk-Olsen T, Bergink V.  J Affect Disord. 2017 May 3;218:394-397.

In women with bipolar disorder, prophylactic use of lamotrigine during the postpartum period decreased risk for relapse.

Web-based integrated bipolar parenting intervention for parents with bipolar disorder: a randomised controlled pilot trial.

Jones SH, Jovanoska J, Calam R, Wainwright LD, Vincent H, Asar O, Diggle PJ, Parker R, Long R, Sanders M, Lobban F.  J Child Psychol Psychiatry. 2017 May 16.

Child behaviour, parenting sense of competence and parenting stress improved significantly in IBPI compared to WL to end of intervention, sustained to 48 weeks.

Cognitive-affective depression and somatic symptoms clusters are differentially associated with maternal parenting and coparenting.

Lamela D, Jongenelen I, Morais A, Figueiredo B.  J Affect Disord. 2017 May 10;219:37-48.

In a study which included community mothers (with and without exposure to intimate partner violence), three depression-somatic symptom clusters were identified: no symptoms, high depression and low nonspecific somatic symptoms, and high depression and nonspecific somatic symptoms.  The highest levels of child physical maltreatment risk and overt-conflict coparenting were observed among women in the third group (high depression-somatic symptoms cluster).  









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