The Food and Drug Administration has approved a new progestin-only oral contraceptive called Slynd. This preparation contains the novel progestin drospirenone which is one component of the oral contraceptives (OCs) YaZ and Yasmin. (These contraceptives also contain the estrogen ethinyl estradiol.)
Contraceptives containing only progesterone have raised concerns with regard to their impact on mood. There is evidence that Depo-Provera may increase risk for depression, including postpartum depression. Less clear is if oral progestogen-only contraceptives increase risk for depression. According to a recent study, progestogen-only pills were associated with a 1.34-fold increase in risk for depression, which is similar to what is observed in combined oral contraceptives containing both estrogen and progestogen (RR of 1.23).
What is interesting about this new contraceptive Slynd is that it contains the progestin drospirenone, which is related to spironolactone. When drospirenone was first included in the oral contraceptives Yaz and Yasmin, there was much excitement because it was believed that drospirenone may have less impact on mood and may actually have beneficial effects for certain women.
We do not yet have any information on the impact of Slynd on mood. We tend to think of estrogen as having a beneficial effect on mood, so it is possible that drospirenone alone may behave differently. Another difference is that Slynd contains 4 mg of drospirenone whereas Yaz and Yasmin contain 3 mg.
Ruta Nonacs, MD PhD
Slynd Product Label (FDA)
I have just taken Slynd for a month. Since it is newer, my insurance doesn’t cover it and it is super expensive; so I would be switching either way. I have major depressive disorder and generalized anxiety disorder. Both have been well under control for several years. My anxiety has very, very mild flares, during situations that would likely trigger some anxiousness for many people. On Slynd, I have been in a constant debilitating, high anxiety state; since about a week after starting it. I am irritable, short tempered, and have had mild crying spells every few days.
I have been taking Slynd for two months now i haven’t experienced mood swings anxiety or depression i barely have cramps. However major breakouts like a teenager I’m 38 but the period seems to last almost two weeks it just seems like constant spotting