Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women.  Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep disturbance.

In BREEZE 3, 600 postmenopausal women (mean age, 54.0 years) were randomized to receive gabapentin ER 1800 mg daily (600 mg in the AM and 1200 mg in the PM) or placebo.  Gabapentin decreased the frequency and severity of reported hot flashes. Sleep quality also improved in the gabapentin group.

Gabapentin ER was well-tolerated.  The most commonly reported adverse events in the gabapentin and placebo groups were dizziness (13% vs. 3%), headache (9% vs. 8%), and somnolence (6% vs. 3%).

Read More:  Gabapentin Improves Menopausal Hot Flashes, Insomnia (Medscape)