This week, we have two studies from the Center for Women’s Mental Health — one looking at risk for gestational diabetes in women treated with second generation antipsychotic medications during pregnancy and the other on the use of vortioxetine in perimenopausal women.  

Ruta Nonacs, MD PhD

Gestational Weight Gain and Pre-pregnancy Body Mass Index Associated With Second-Generation Antipsychotic Drug Use During Pregnancy.

Freeman MP, Sosinsky AZ, Goez-Mogollon L, Savella GM, Moustafa D, Viguera AC, Cohen LS.  Psychosomatics. 2017 Sep 21.

Women exposed to SGAs began pregnancy with higher BMIs than controls. Both exposed and unexposed groups experienced similar weight gain during pregnancy.

Vortioxetine for major depressive disorder, vasomotor, and cognitive symptoms associated with the menopausal transition.

Freeman MP, Cheng LJ, Moustafa D, Davies A, Sosinsky AZ, Wang B, Petrillo LF, Hogan C, Cohen LS.  Ann Clin Psychiatry. 2017 Nov;29(4):249-257.

The depression response rate (?50% reduction in MADRS) and remission rate (final MADRS ?10) were 75% and 70.8%, respectively. Improvement was also noted on the Menopause-Specific Quality of Life Questionnaire (MEN-QOL), Beck Anxiety Inventory (BAI), and Cognitive and Physical Functioning Questionnaire (CPFQ).

Generating an efficient version of the Edinburgh Postnatal Depression Scale in an urban obstetrical population.

Gollan JK, Wisniewski SR, Luther JF, Eng HF, Dills JL, Sit D, Ciolino JD, Wisner KL.  J Affect Disord. 2017 Jan 15;208:615-620.

The seven-item one factor version of the EPDS is an efficient and effective measure of depression severity on par with the 10-item version of the EPDS.

Program In Support of Moms (PRISM): a pilot group randomized controlled trial of two approaches to improving depression among perinatal women.

Byatt N, Moore Simas TA, Biebel K, Sankaran P, Pbert L, Weinreb L, Ziedonis D, Allison J.  J Psychosom Obstet Gynaecol. 2017 Oct 10:1-10.

Among MCPAP for Moms alone practices, patients’ (n?=?9) EPDS scores improved from 15.22 to 10.11 (p?=?0.010), whereas in PRISM practices patients’ (n?=?21) EPDS scores improved from 13.57 to 6.19 (p?=?0.001).

Maternal self-confidence during the first four months postpartum and its association with anxiety and early infant regulatory problems.

Matthies LM, Wallwiener S, Müller M, Doster A, Plewniok K, Feller S, Sohn C, Wallwiener M, Reck C.  Infant Behav Dev. 2017 Oct 5;49:228-237.

Maternal self-confidence increased significantly over the course of the postpartum period. High maternal trait anxiety and early infant regulatory problems negatively contributed to the prediction of maternal self-confidence, explaining 31.8% of the variance

Relationship of bipolar disorder with psychiatric comorbidity in the postpartum period-a scoping review.

Sharma V.  Arch Womens Ment Health. 2017 Oct 24. Review.

Predictors of Postpartum Return to Smoking: A Systematic Review.

Orton S, Coleman T, Coleman-Haynes T, Ussher M.  Nicotine Tob Res. 2017 Jul 25.

Predictors of relapse include intending to quit smoking only for the duration of pregnancy, partner/household member smoking and confidence to remain abstinent are those most likely to have a direct, causal impact on smoking behavior after childbirth.

Human milk cortisol concentration predicts experimentally induced infant fear reactivity: moderation by infant sex.

Nolvi S, Uusitupa HM, Bridgett DJ, Pesonen H, Aatsinki AK, Kataja EL, Korja R, Karlsson H, Karlsson L.  Dev Sci. 2017 Oct 27.

Higher human milk cortisol concentrations are associated with elevated experimentally induced fear in infancy. Findings support lactocrine programming, and suggest that mothers may “communicate” vital information about stressful environments via cortisol contained in breast milk, shaping girls’ early emotional reactivity.

Maternal psychological distress after preterm birth: Disruptive or adaptive?

Hall RAS, Hoffenkamp HN, Braeken J, Tooten A, Vingerhoets AJJM, van Bakel HJA.  Infant Behav Dev. 2017 Oct 23;49:272-280.

While heightened distress levels seem inherent to preterm birth, there appears to be substantial heterogeneity in mothers’ emotional responsivity. This study indicates that relatively high levels of distress after preterm birth do not necessarily place these mothers at increased risk with regard to poor parenting. Conversely, low distress levels do not necessarily indicate good-quality parenting.

A population-based study of the relationship between perinatal depressive symptoms and breastfeeding: a cross-lagged panel study.

Haga SM, Lisøy C, Drozd F, Valla L, Slinning K.  Arch Womens Ment Health. 2017 Oct 23.

There was no evidence of a relationship between depressive symptoms and breastfeeding.

The prevalence of posttraumatic stress disorder in pregnancy and after birth: A systematic review and meta-analysis.

Yildiz PD, Ayers S, Phillips L.  J Affect Disord. 2017 Jan 15;208:634-645.

Women in high-risk groups were at higher risk for PTSD with a mean prevalence of 18.95% (95%, CI 10.62-31.43) in pregnancy and 18.5% (95%, CI 10.6-30.38) after birth. \

Depression Treatment by Non-Mental-Health Providers: Incremental Evidence for the Effectiveness of Listening Visits.

Brock RL, O’Hara MW, Segre LS.  Am J Community Psychol. 2017 Mar;59(1-2):172-183.  Free Article

Participants receiving LV during the follow-up period experienced significant improvement in depressive symptoms.

Goodness of fit between prenatal maternal sleep and infant sleep: Associations with maternal depression and attachment security.

Newland RP, Parade SH, Dickstein S, Seifer R.  Infant Behav Dev. 2016 Aug;44:179-88.  Free Article


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