Every week we review the most recent publications in women’s mental health, covering topics related to premenstrual symptoms, perinatal mood and anxiety disorders, use of medications in pregnant and breastfeeding women, perinatal substance use, and menopausal mental health.

For more detailed descriptions of many of these topics, you can sign up to receive our weekly CWMH NEWSLETTER which comes out every Thursday.

Ruta Nonacs, MD PhD


Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial.

Eisenlohr-Moul TA, Bowers SM, Prinstein MJ, Schmalenberger KM, Walsh EC, Young SL, Rubinow DR, Girdler SS. Transl Psychiatry. 2022 Dec 30;12(1):528.

Experimental administration of estradiol and progesterone reduced perimenstrual exacerbation of suicidal ideation, suicide planning, depression, hopelessness, perceived stress, rejection sensitivity, and perceived burdensomeness, particularly in the perimenstrual (natural estradiol and progesterone withdrawal) days.


No articles this week


Association between high levels of comorbid anxiety and depressive symptoms and decreased likelihood of birth without intervention: A longitudinal prospective cohort study.

Hulsbosch LP, Boekhorst MGBM, Lodder P, Potharst ES, Nyklí?ek I, Bergink V, Oei SG, Verhoeven CJM, Pop VJM. BJOG. 2023 Apr;130(5):495-505.

Persistently high levels of comorbid anxiety and depressive symptoms were associated with a lower likelihood of birth without intervention (odds ratio 0.67, 95% confidence interval 0.47-0.95, P = 0.027) compared with the reference group (persistently low levels of symptoms), after adjusting for confounders.

Threat versus deprivation in mother’s childhood: Differential relations to hair cortisol and psychopathology in pregnancy.

Penner F, Khoury JE, Bosquet Enlow M, Lyons-Ruth K. Child Abuse Negl. 2023 Mar 2;139:106107.

Greater severity of abuse, but not neglect, in childhood was associated with higher maternal depressive symptoms during pregnancy. In contrast, greater severity of neglect, but not abuse, in mothers’ childhood was associated with lower maternal hair cortisol concentration.

Effects of a Mindfulness-Based Parental Reflection Intervention on Pregnancy-Related Distress: A Pilot Study.

Ciciolla L, Addante S, Shreffler KM, Croff JM. Womens Health Rep (New Rochelle). 2023 Feb 9;4(1):78-83. doi: 10.1089/whr.2022.0090. eCollection 2023.


A Clinical Review of the Use of Common Psychiatric Medications in Pregnancy: Guidelines for Obstetrical Providers.

Lubotzky-Gete S, Barker LC, Vigod SN. Obstet Gynecol Clin North Am. 2023 Mar;50(1):219-227.


Postpartum Depression: Screening and Collaborative Management.

Wells T. Prim Care. 2023 Mar;50(1):127-142.

Effect of pre-administration of esketamine intraoperatively on postpartum depression after cesarean section: A randomized, double-blinded controlled trial.

Wang W, Ling B, Chen Q, Xu H, Lv J, Yu W. Medicine (Baltimore). 2023 Mar 3;102(9):e33086.

Esketamine was administered intravenously at a dose of 0.2 mg/kg after the infant was delivered in group E and equal volume of normal saline was given in group C. The incidence of postpartum depression was significantly lower at 1 week and 6 weeks after surgery in group E (P < .01) compared to group C.

Identifying women with postdelivery posttraumatic stress disorder using natural language processing of personal childbirth narratives.

Bartal A, Jagodnik KM, Chan SJ, Babu MS, Dekel S.

The machine learning model derived from natural language processing of childbirth narratives achieved good performance in terms of identifying women with childbirth-related PTSD.

Obstetric complications and clinical presentation in first episode of psychosis.

Verdolini N, Mezquida G, Valli I, Garcia-Rizo C, Cuesta M, Vieta E, Bioque M, Lobo A, González-Pinto A, Pina-Camacho L, Corripio I, Garriga M, Baeza I, Martínez-Sadurní L, Bitanihirwe B, Cannon M, Bernardo M. Acta Neuropsychiatr. 2023 Mar 2:1-29.

In a group of 277 women with first episode of psychosis after childbirth, total number of obstetric complications and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use.

The relationship of childbirth experience with postpartum depression and anxiety: a cross-sectional study.

Ahmadpour P, Faroughi F, Mirghafourvand M. BMC Psychol. 2023 Mar 3;11(1):58.

Postpartum depression and anxiety are related to childbirth experiences, therefore considering the effects of mothers’ mental health on other aspects of a woman and her family’s life, the core role of health care providers and policymakers in creating positive childbirth experiences is determined.


No articles this week


No articles this week


Stability of maternal postnatal bonding between 3 and 6 months: Associations with maternal mental health and infant temperament.

Capelli E, Anceresi G, Grumi S, Provenzi L. Infant Behav Dev. 2023 Feb 28;71:101826.

At 3 months, higher levels of maternal bonding were predicted by lower levels of anxiety and depression in the mothers and by higher infants’ regulation scores. At 6 months, lower levels of anxiety and depression predicted higher levels of bonding.


Natural vs. surgical postmenopause and psychological symptoms confound the effect of menopause on executive functioning domains of cognitive experience.

Page CE, Soreth B, Metcalf CA, Johnson RL, Duffy KA, Sammel MD, Loughead J, Epperson CN. Maturitas. 2023 Apr;170:64-73.

BADDS scores were significantly elevated (indicating more difficulties in executive function) among women in the perimenopausal and surgical postmenopausal groups compared with those in the premenopausal group. Likewise, the perimenopausal and surgical postmenopausal groups had the highest proportions of participants who reported difficulty sleeping and clinical levels of anxiety and depression.


No articles this week

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