We are now open for those who would like to register for our online course in Women’s Mental Health.  This course will focus on the diagnosis and treatment of psychiatric disorders in women across the reproductive lifespan.

In addition to videotaped seminars, course participants will also be able to engage with the faculty in question and answer and case-based discussion sessions. Readings to accompany course materials will also be provided.

You can learn more about the program and register HERE.

For more detailed descriptions of many of these topics, you can read the CWMH NEWSLETTER which comes out every Thursday.  You can sign up for our newsletter HERE.

 

Ruta Nonacs, MD PhD

 

PMS AND PMDD

No articles this week

 

INFERTILITY AND MENTAL HEALTH

Prevalence of depression and anxiety in women with recurrent pregnancy loss and the associated risk factors.

He L, Wang T, Xu H, Chen C, Liu Z, Kang X, Zhao A.  Arch Gynecol Obstet. 2019 Aug 21. 

In women with recurrent pregnancy loss, those with lower education level (lower than university), lower household income (<?10,000 yuan) and history of induced abortion had significantly higher levels of depression and anxiety. Women with multiple pregnancy losses (???3) and no live birth had significantly higher depressive symptoms. 

 

PSYCHIATRIC ILLNESS DURING PREGNANCY

Increase of depressive symptomatology during pregnancy over 25 years’ time in four population based cohorts.

Pop V, van Son M, Wijnen H, Spek V, Denollet J, Bergink V.  J Affect Disord. 2019 Aug 19;259:175-179. 

From 1988 to 2014, Mean EDS scores during the first and third trimester of pregnancy increased significantly (P < 0.001). The number of women with elevated EDS scores doubled from 7% in 1988-1989 to 14% in 2012-2014 (P?=?0.001). The number of highly educated women increased from 23% to 66% and those with paid employment from 75% to 95%, while smoking and alcohol use decreased significantly (all Ps < 0.001). These trends were similar to those of the National Statistics. A previous history of depression, multi-parity and paid employment were associated with higher EDS scores.

 

Associations of antepartum suicidal behaviour with adverse infant and obstetric outcomes.

Zhong QY, Gelaye B, Karlson EW, Avillach P, Smoller JW, Cai T, Williams MA. Paediatr Perinat Epidemiol. 2019 Mar;33(2):137-144.

The prevalence of antepartum suicidal behaviour was 152.44 per 100 000 singleton livebirths. Nearly two-thirds (64.24%) of women with suicidal behaviour also had psychiatric disorders. Compared to women without psychiatric disorders and suicidal behaviour, women with psychiatric disorders alone had 1.3-fold to 1.4-fold increased odds of delivering low birthweight or preterm infants and 1.2-fold increased odds of experiencing obstetric complications. Women with suicidal behaviour alone had increased odds of preterm labour (aOR 2.05, 95% CI 1.16, 3.62). Women with both suicidal behaviour and psychiatric disorders had > twofold increased odds of delivering low birthweight (aOR 2.52, 95% CI 1.40, 4.54), preterm birth (aOR 2.44, 95% CI 1.63, 3.66), and low birthweight/preterm birth (aOR 2.30, 95% CI 1.54, 3.44) infants; the odds of preterm labour (aOR 1.62, 95% CI 1.06, 2.47), placental abruption (aOR 2.33, 95% CI 1.20, 4.51), preterm rupture of membranes (aOR 1.63, 95% CI 1.08, 2.46), and postpartum haemorrhage (aOR 1.93, 95%CI 1.09, 3.40) were elevated.

 

Internet-delivered psychological interventions for clinical anxiety and depression in perinatal women: a systematic review and meta-analysis.

Loughnan SA, Joubert AE, Grierson A, Andrews G, Newby JM.  Arch Womens Ment Health. 2019 May 17. 

Of the seven studies included, two were open trials and five were randomized controlled trials with a total of 595 participants. Preliminary findings indicate large improvements in depression and anxiety from pre- to post-treatment.

 

MEDICATIONS AND PREGNANCY

No articles this week

 

POSTPARTUM PSYCHIATRIC ILLNESS

Preterm birth as a risk factor for postpartum depression: A systematic review and meta-analysis.

de Paula Eduardo JAF, de Rezende MG, Menezes PR, Del-Ben CM.  J Affect Disord. 2019 Aug 21;259:392-403.

Most of the studies supported the association between preterm birth (PTB) and postpartum depression (PPD). However, 8 studies did not find such association and, even among studies with positive findings, results were heterogeneous, given the methodological discrepancies among the studies. The meta-analysis provided evidence of higher risk for PPD among mothers of preterm infants in assessments performed up to 24 weeks after childbirth.

 

Evaluation of a Technology-Based Peer-Support Intervention Program for Preventing Postnatal Depression (Part 2): Qualitative Study.

Shorey S, Ng ED.  J Med Internet Res. 2019 Aug 29;21(8):e12915. Free Article

 

Do maternal depression and self-esteem moderate and mediate the association between intimate partner violence after childbirth and postpartum suicidal ideation?

Islam MJ, Broidy L, Mazerolle P, Baird K, Mazumder N, Zobair KM.  Arch Suicide Res. 2019 Aug 28:1-41.

The prevalence of postpartum suicidal (SI) was 30.8%. Accounting the influence of other confounders, the odds of postpartum SI were significantly higher among women who reported physical IPV victimization (AOR: 2.65; 95% CI =1.36, 5.18) at any point during the first six months following childbirth as opposed to those who did not.

 

Prenatal and Postnatal Hair Steroid Levels Predict Post-Partum Depression 12 Weeks after Delivery.

Jahangard L, Mikoteit T, Bahiraei S, Zamanibonab M, Haghighi M, Sadeghi Bahmani D, Brand S.  J Clin Med. 2019 Aug 23;8(9). Free Article

Compared to those of women without PPD, hair steroid levels (cortisol, cortisone, progesterone) were significantly lower in women with PPD both before and after delivery. Lower prenatal cortisone and progesterone levels predicted higher depression scores 12 weeks after delivery.

 

Peritraumatic dissociation in childbirth-evoked posttraumatic stress and postpartum mental health.

Thiel F, Dekel S.  Arch Womens Ment Health. 2019 May 21.

Women who had assisted vaginal deliveries or unscheduled Cesareans reported higher peritraumatic dissociation levels than those who had regular vaginal deliveries or scheduled Cesareans. Peritraumatic dissociation predicted PP-PTSD above and beyond premorbid and other childbirth-related factors.

 

Is childbirth-induced PTSD associated with low maternal attachment?

Dekel S, Thiel F, Dishy G, Ashenfarb AL.  Arch Womens Ment Health. 2019 Feb;22(1):119-122.

Attachment was lower in women with PP-PTSD compared to non-childbirth-related PTSD and no PP-PTSD. 

 

The course and clinical correlates of obsessive-compulsive disorder during the postpartum period: A naturalistic observational study.

Yakut E, Uguz F, Aydogan S, Bayman MG, Gezginc K.  J Affect Disord. 2019 Jul 1;254:69-73. 

Patients with OCD who exhibit hyperthymic affective temperament character and a decrease in symptoms following a previous childbirth may experience a significant alleviation in the severity of obsessive-compulsive symptoms during the postpartum period.

 

Combined effect of adverse childhood experiences and young age on self-harm ideation among postpartum women in Japan.

Doi S, Fujiwara T.  J Affect Disord. 2019 Jun 15;253:410-418.

Postpartum women with 3 or more ACEs and younger age (<25 years old) were 10.3 times more likely than those with no ACEs and older age to have self-harm ideation (95%CI = 5.3-20.2). 

 

MEDICATIONS AND BREASTFEEDING

No articles this week

 

PERINATAL SUBSTANCE USE DISORDERS

No articles this week

 

MATERNAL MENTAL HEALTH AND CHILD OUTCOMES

No articles this week

 

MENOPAUSE AND MENTAL HEALTH

No articles this week

 

OTHER TOPICS IN WOMEN’S MENTAL HEALTH

Effect of Adjunctive Estradiol on Schizophrenia Among Women of Childbearing Age: A Randomized Clinical Trial.

Weiser M, Levi L, Zamora D, Biegon A, SanGiovanni JP, Davidson M, Burshtein S, Gonen I, Radu P, Slobozean Pavalache K, Nastas I, Hemi R, Ryan T, Davis JM.  JAMA Psychiatry. 2019 Jul 31. 

Transdermal estradiol is an effective add-on treatment for women of childbearing age with schizophrenia leading to improvements in negative symptoms; however, the effect could be specific to those older than 38 years.