|Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy.
Lee H, Koh JW, Kim YA, Chun KC, Han JY, Hwang JH, Choi JS, Joo SH, Kwon HY. Front Pharmacol. 2022 Apr 25;13:854562.
In a prospective study of alprazolam-exposed (N = 96) and non-exposed (N = 629) women, use of alprazolam was associated with the following outcomes: spontaneous abortion (OR = 2.38; 95% CI 1.20-4.69), LBW (OR = 3.65; 95% CI 1.22-11.00), and Apgar score at 1 min ? 7 (OR = 2.19; 95% CI 1.02-4.67). There was no significant difference in congenital abnormalities between the exposure and non-exposure groups.
Hypnotic Benzodiazepine Receptor Agonist exposure during pregnancy and the risk of congenital malformations and other adverse pregnancy outcomes: A systematic review and meta-analysis.
Grigoriadis S, Alibrahim A, Mansfield JK, Sullovey A, Robinson GE. Acta Psychiatr Scand. 2022 Apr 29.
Five studies were pooled to evaluate risk of congenital malformations following first trimester exposure; there was no statistically significant association (OR 0.87, 95% CI 0.56-1.36).
Prenatal exposure to benzodiazepines and Z-drugs in humans and risk of adverse neurodevelopmental outcomes in offspring: A systematic review.
Wang X, Zhang T, Ekheden I, Chang Z, Hellner C, Jan Hasselström, Jayaram-Lindström N, M D’Onofrio B, Larsson H, Mataix-Cols D, Sidorchuk A. Neurosci Biobehav Rev. 2022 Apr 1;137:104647.
Due to the inconsistencies across studies, it was not possible to reach a conclusion.
First-trimester exposure to benzodiazepines and risk of congenital malformations in offspring: A population-based cohort study in South Korea.
Noh Y, Lee H, Choi A, Kwon JS, Choe SA, Chae J, Kim DS, Shin JY. PLoS Med. 2022 Mar 2;19(3):e1003945. Free PMC article.
Among a total of 3,094,227 pregnancies, 40,846 (1.3%) were exposed to benzodiazepines during the first trimester. The adjusted RR was 1.09 (95% CI 1.05 to 1.13, p < 0.001) for overall risk of malformations and 1.15 (1.10 to 1.21, p < 0.001) for heart defects.
Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register-Based Cohort Study in Sweden.
Heinonen E, Forsberg L, Nörby U, Wide K, Källén K. CNS Drugs. 2022 May;36(5):529-539.
The adjusted risk ratio for gestational diabetes for women treated with high-risk metabolic second-generation antipsychotics during pregnancy was 1.8 (95% CI 1.3-2.4) compared to untreated women. Other antipsychotics were not associated with metabolic risks.
Prenatal exposure to benzodiazepines and the development of the offspring – a systematic review.
Jensen AG, Knudsen SS, Bech BH. Neurotoxicol Teratol. 2022 Feb 18;91:107078.
Prenatal exposure to benzodiazepines was associated with worse neurodevelopmental outcomes; however, results were contradicting, and it cannot be ruled out that the findings might be due to bias.