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No articles this week


No articles this week


Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy.

Lee H, Koh JW, Kim YA, Chun KC, Han JY, Hwang JH, Choi JS, Joo SH, Kwon HY. Front Pharmacol. 2022 Apr 25;13:854562.

In a prospective study of alprazolam-exposed (N = 96) and non-exposed (N = 629) women, use of alprazolam was associated with the following outcomes: spontaneous abortion (OR = 2.38; 95% CI 1.20-4.69), LBW (OR = 3.65; 95% CI 1.22-11.00), and Apgar score at 1 min ? 7 (OR = 2.19; 95% CI 1.02-4.67). There was no significant difference in congenital abnormalities between the exposure and non-exposure groups.

Hypnotic Benzodiazepine Receptor Agonist exposure during pregnancy and the risk of congenital malformations and other adverse pregnancy outcomes: A systematic review and meta-analysis.

Grigoriadis S, Alibrahim A, Mansfield JK, Sullovey A, Robinson GE. Acta Psychiatr Scand. 2022 Apr 29.

Five studies were pooled to evaluate risk of congenital malformations following first trimester exposure; there was no statistically significant association (OR 0.87, 95% CI 0.56-1.36).

Prenatal exposure to benzodiazepines and Z-drugs in humans and risk of adverse neurodevelopmental outcomes in offspring: A systematic review.

Wang X, Zhang T, Ekheden I, Chang Z, Hellner C, Jan Hasselström, Jayaram-Lindström N, M D’Onofrio B, Larsson H, Mataix-Cols D, Sidorchuk A. Neurosci Biobehav Rev. 2022 Apr 1;137:104647.

Due to the inconsistencies across studies, it was not possible to reach a conclusion.

First-trimester exposure to benzodiazepines and risk of congenital malformations in offspring: A population-based cohort study in South Korea.

Noh Y, Lee H, Choi A, Kwon JS, Choe SA, Chae J, Kim DS, Shin JY. PLoS Med. 2022 Mar 2;19(3):e1003945. Free PMC article.

Among a total of 3,094,227 pregnancies, 40,846 (1.3%) were exposed to benzodiazepines during the first trimester. The adjusted RR was 1.09 (95% CI 1.05 to 1.13, p < 0.001) for overall risk of malformations and 1.15 (1.10 to 1.21, p < 0.001) for heart defects.

Antipsychotic Use During Pregnancy and Risk for Gestational Diabetes: A National Register-Based Cohort Study in Sweden.

Heinonen E, Forsberg L, Nörby U, Wide K, Källén K. CNS Drugs. 2022 May;36(5):529-539.

The adjusted risk ratio for gestational diabetes for women treated with high-risk metabolic second-generation antipsychotics during pregnancy was 1.8 (95% CI 1.3-2.4) compared to untreated women. Other antipsychotics were not associated with metabolic risks.

Prenatal exposure to benzodiazepines and the development of the offspring – a systematic review.

Jensen AG, Knudsen SS, Bech BH. Neurotoxicol Teratol. 2022 Feb 18;91:107078.

Prenatal exposure to benzodiazepines was associated with worse neurodevelopmental outcomes; however, results were contradicting, and it cannot be ruled out that the findings might be due to bias.


Predicting perinatal health outcomes using smartphone-based digital phenotyping and machine learning in a prospective Swedish cohort (Mom2B): study protocol.

Bilal AM, Fransson E, Bränn E, Eriksson A, Zhong M, Gidén K, Elofsson U, Axfors C, Skalkidou A, Papadopoulos FC. BMJ Open. 2022 Apr 27;12(4):e059033. Free PMC article.

The Mom2B smartphone app will be tested in 5000 Swedish women. Active data collection consists of surveys related to participant background information, mental and physical health, lifestyle, and social circumstances, as well as voice recordings. Participants’ general smartphone activity, geographical movement patterns, social media activity and cognitive patterns can be estimated through passive data collection from smartphone sensors and activity logs.

A comparison of symptoms of bipolar and unipolar depression in postpartum women.

Clark CT, Sit DK, Zumpf KB, Ciolino JD, Yang A, Fisher SD, Wisner KL. J Affect Disord. 2022 Apr 15;303:82-90.

Measurement and conceptualization of maternal PTSD following childbirth: Psychometric properties of the City Birth Trauma Scale-French Version (City BiTS-F).

Sandoz V, Hingray C, Stuijfzand S, Lacroix A, El Hage W, Horsch A. Psychol Trauma. 2022 May;14(4):696-704.

A single intravenous administration of a sub-anesthetic ketamine dose during the perioperative period of cesarean section for preventing postpartum depression: A meta-analysis.

Li Q, Wang S, Mei X. Psychiatry Res. 2022 Apr;310:114396.

Meta-analysis showed that in ketamine group, the score and the prevalence of PPD within 1 week postpartum were significantly reduced, whereas PPD score after 4 weeks postpartum showed no superiority.

Comparison of Estimated Incentives for Preventing Postpartum Depression in Value-Based Payment Models Using the Net Present Value of Care vs Total Cost of Care.

Counts NZ, Kuklinski MR, Wong V, Feinberg ME, Creedon TB. JAMA Netw Open. 2022 Apr 1;5(4):e229401. Free PMC article.

Providing preventive interventions for postpartum depression resulted in an estimated 5-year savings of $734.12) per person. Without health insurance churn, sharing 50% of 5-year expected savings could offer more than double the financial incentives for clinicians to prevent postpartum depression compared with traditional value-based payment (VBP, $367.06 vs $177.74, respectively), with a high likelihood of positive return for the health care payer (91%).


No articles this week


Association Between Prenatal Cannabis Use and Psychotropic Medication Use in Pregnant Patients With Depression and Anxiety.

Hirschtritt ME, Avalos LA, Sarovar V, Ridout KK, Goler NC, Ansley DR, Satre DD, Young-Wolff KC. J Addict Med. 2022 Jan 11.

Impact of prenatal tobacco smoking on infant telomere length trajectory and ADHD symptoms at 18?months: a longitudinal cohort study.

Howell MP, Jones CW, Herman CA, Mayne CV, Fernandez C, Theall KP, Esteves KC, Drury SS. BMC Med. 2022 Apr 28;20(1):153. Free PMC article.

Consistent with previous cross-sectional studies linking shorter offspring TL to maternal prenatal smoking, maternal prenatal smoking predicted greater telomere shortening from 4 to 18 months of infant age. Maternal depression was positively associated with both prenatal smoking (odds ratio (OR): 4.614, 95% CI [1.733, 12.282]; p = 0.002) and child ADHD symptoms (? = 4.713, 95% CI [2.073, 7.354]; p = 0.0006).


Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months.

Wu Y, Espinosa KM, Barnett SD, Kapse A, Quistorff JL, Lopez C, Andescavage N, Pradhan S, Lu YC, Kapse K, Henderson D, Vezina G, Wessel D, du Plessis AJ, Limperopoulos C. JAMA Netw Open. 2022 Apr 1;5(4):e229244. Free PMC article.

Altered prenatal brain development in the setting of elevated maternal distress has adverse infant sociocognitive outcomes. Identifying early biomarkers associated with long-term neurodevelopment may assist in early targeted interventions.


No articles this week


C-Reactive protein concentrations in reproductive-aged women with major mood disorders.

Torres E, Zumpf KB, Ciolino JD, Clark CT, Sit DK, Miller ES, Wisner KL. Arch Womens Ment Health. 2022 Jun;25(3):577-584.

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