This week brings a large scale study on the reproductive safety of the newer atypical antipsychotic medications from Huybrechts and colleagues.  To date, this is the largest sample of antipsychotic-exposed infants assessed, and the results look good, suggesting that the use of atypical antipsychotics during the first trimester of pregnancy does not seem to increase risk for congenital malformations.

Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations.

Huybrechts KF, Hernández-Díaz S, Patorno E, Desai RJ, Mogun H, Dejene SZ, Cohen JM, Panchaud A, Cohen L, Bateman BT.

JAMA Psychiatry. 2016 Aug 17.

Postpartum psychiatric emergency visits: a nested case-control study.

Barker LC, Kurdyak P, Fung K, Matheson FI, Vigod S.

Arch Womens Ment Health. 2016 Aug 11. [Epub ahead of print]

Maternal Health Factors as Risks for Postnatal Depression: A Prospective Longitudinal Study.

Chojenta CL, Lucke JC, Forder PM, Loxton DJ.

PLoS One. 2016 Jan 19;11(1):e0147246. Free Article

Couple comorbidity and correlates of postnatal depressive symptoms in mothers and fathers in the first two weeks following delivery.

Anding JE, Röhrle B, Grieshop M, Schücking B, Christiansen H.

J Affect Disord. 2016 Jan 15;190:300-9.

Smoking Before and During Pregnancy Among Women Reporting Depression or Anxiety.

Tong VT, Farr SL, Bombard J, D?Angelo D, Ko JY, England LJ.

Obstet Gynecol. 2016 Aug 5. [Epub ahead of print]

Prospective assessment of autism traits in children exposed to antiepileptic drugs during pregnancy.

Wood AG, Nadebaum C, Anderson V, Reutens D, Barton S, O’Brien TJ, Vajda F.

Epilepsia. 2015 Jul;56(7):1047-55. Free Article

Summary:  Prenatal exposure to valproate was associated with increased risk of autistic traits.  The most important determinant of increased risk was higher doses of sodium valproate exposure.

Effects of stretching on menopausal and depressive symptoms in middle-aged women: arandomized controlled trial.

Kai Y, Nagamatsu T, Kitabatake Y, Sensui H.

Menopause. 2016 Aug;23(8):827-32.

Do changes in subjective sleep and biological rhythms predict worsening in postpartum depressive symptoms? A prospective study across the perinatal period.

Krawczak EM, Minuzzi L, Hidalgo MP, Frey BN.

Arch Womens Ment Health. 2016 Aug;19(4):591-8.

The Risk of Specific Congenital Anomalies in Relation to Newer Antiepileptic Drugs: A Literature Review.

de Jong J, Garne E, de Jong-van den Berg LT, Wang H.

Drugs Real World Outcomes. 2016 May 24;3(2):131-143. Review.  Free Article

Maternal depressive symptoms at three months postpartum and breastfeeding rates at six months postpartum: Implications for primary care in a prospective cohort study of primiparous women in Australia.

Woolhouse H, James J, Gartland D, McDonald E, Brown SJ.

Women Birth. 2016 Jul 19.

Identification of depression in women during pregnancy and the early postnatal period using the Whooley questions and the Edinburgh Postnatal Depression Scale: protocol for the Born and Bred in Yorkshire: PeriNatal Depression Diagnostic Accuracy (BaBY PaNDA) study.

Littlewood E, Ali S, Ansell P, Dyson L, Gascoyne S, Hewitt C, Keding A, Mann R, McMillan D, Morgan D, Swan K, Waterhouse B, Gilbody S; BaBY PaNDA study team.

BMJ Open. 2016 Jun 13;6(6):e011223.

Mother-Infant Emotion Regulation at Three Months: The Role of Maternal Anxiety, Depression and Parenting Stress.

Riva Crugnola C, Ierardi E, Ferro V, Gallucci M, Parodi C, Astengo M.

Psychopathology. 2016 Jul 14. [Epub ahead of print]

Factors associated with onset timing, symptoms, and severity of depression identified in the postpartum period.

Fisher SD, Wisner KL, Clark CT, Sit DK, Luther JF, Wisniewski S.

J Affect Disord. 2016 Oct;203:111-20. Epub 2016 May 28.


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