Mass General Hospital

Harvard Medical School

Weekly Roundup for APRIL 7, 2017: Recent Publications in Women’s Mental Health

 

Lots of good reviews on the list this week:  Postpartum OCD (Roussos-Ross and Nguyen), Role of Reproductive Steroids in Mood and Behavior (Schiller et al), Efficacy of Interventions Treating Mood and Anxiety Disorders During Pregnancy (van Ravesteyn et al), Efficacy of Chinese Herbal Medicines for Perinatal Mood and Anxiety Disorders (Li et al), Perinatal Depression in the Military (Klaman and Turner), and the Effects of Paternal Perinatal Depression on the Child (Gentile and Fusco).

Ruta Nonacs, MD PhD


Postpartum Acute Care Utilization Among Women with Intellectual and Developmental Disabilities.

Brown HK, Cobigo V, Lunsky Y, Vigod S.  J Womens Health (Larchmt). 2017 Jan 24.

Women with intellectual and developmental disabilities, compared to those without, were at increased risk for postpartum hospital admissions (2.4% vs. 1.2%; adjusted hazard ratios [aHR]: 1.76).  Hospitalization for psychiatric reasons was markedly elevated (0.8% vs. 0.1%; aHR: 10.46); there was no increase in risk for hospitalization for medical reasons.


 A Brief Overview of Post-Partum Obsessive Compulsive Disorder. 

Roussos-Ross k and Nguyen M. (2017). M J Gyne. 1(1): 006.

This is a good two-page review of postpartum OCD — how to identify and treat.


Anxiety as a risk factor for menopausal hot flashes: evidence from the Penn Ovarian Aging cohort.

Freeman EW, Sammel MD.  Menopause. 2016 Sep;23(9):942-9.

Women with high levels of somatic anxiety had the greatest risk of hot flashes.  Less risk was associated with somatic anxiety.  (Somatic anxiety encompasses physical symptoms of anxiety, such as butterflies in the stomach.)


Reproductive Steroid Regulation of Mood and Behavior.

Schiller CE, Johnson SL, Abate AC, Schmidt PJ, Rubinow DR.  Compr Physiol. 2016 Jun 13;6(3):1135-60.

A review on how reproductive hormones affect mood and behavior, specifically discussing reproductive hormone-related mood disorders (premenstrual dysphoric disorder, postpartum depression, and perimenopausal depression).


Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study.

Osborne LM, Gispen F, Sanyal A, Yenokyan G, Meilman S, Payne JL.  Psychoneuroendocrinology. 2017 May;79:116-121.

In 60 pregnant women with a prior diagnosis of a mood disorder, lower levels of allopregnanolone predicted PPD.


Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis.

O’Donnell KJ, Meaney MJ.  Am J Psychiatry. 2017 Apr 1;174(4):319-328.

Maternal anxiety, depression, and stress all influence neurodevelopment but show modest, weak, or no associations with known stress mediators (e.g., glucocorticoids) or with fetal growth. Rather, compromised fetal development appears to establish a “meta-plastic” state that increases sensitivity to postnatal influences.


The impact of pre- and post-natal psycho-educational intervention on the construction of parenthood.

Razurel C, Antonietti JP, Rulfi F, Pasquier N, Domingues-Montanari S, Darwiche J.  Arch Womens Ment Health. 2017 Mar 29.

Parental self-efficacy and the mother-child relationship were significantly improved for the group who received a post-natal interview at 2 and 3 months postpartum in addition to a prenatal interview.


Interventions to treat mental disorders during pregnancy: A systematic review and multiple treatment meta-analysis.

van Ravesteyn LM, Lambregtse-van den Berg MP, Hoogendijk WJ, Kamperman AM.  PLoS One. 2017 Mar 30;12(3):e0173397.   Free Article

This meta-analysis found a robust moderate treatment effect of CBT for MDD during pregnancy, and to a lesser extent for IPT.  No treatment studies of pharmacologic treatment were identified.


Infant frontal EEG asymmetry in relation with postnatal maternal depression and parenting behavior.

Wen DJ, Soe NN, Sim LW, Sanmugam S, Kwek K, Chong YS, Gluckman PD, Meaney MJ, Rifkin-Graboi A, Qiu A.  Transl Psychiatry. 2017 Mar 14;7(3):e1057.


The levonorgestrel-releasing intrauterine device potentiates stress reactivity.

Aleknaviciute J, Tulen JH, De Rijke YB, Bouwkamp CG, van der Kroeg M, Timmermans M, Wester VL, Bergink V, Hoogendijk WJ, Tiemeier H, van Rossum EF, Kooiman CG, Kushner SA.

Psychoneuroendocrinology. 2017 Feb 28;80:39-45.

Recent clinical trials have identified side effects of the levonorgestrel-releasing intrauterine device (LNG-IUD) that appear to be systemically mediated, including depressed mood and emotional lability.

This study suggests that women using LNG-IUD had an exaggerated salivary cortisol response.  


Chinese Herbal Medicine for Postpartum Depression: A Systematic Review of Randomized Controlled Trials.

Li Y, Chen Z, Yu N, Yao K, Che Y, Xi Y, Zhai S.  Evid Based Complement Alternat Med. 2016;2016:5284234. Epub 2016 Sep 28.   Free Article

This review concludes that Chinese Herbal Medicines (CHM) alone or in combination with routine treatments could reduce severity of depressive symptoms.  CHM combined with routine treatment was more effective in increasing serum estradiol levels and reducing progesterone levels than routine treatment alone.  


Untreated perinatal paternal depression: Effects on offspring.

Gentile S, Fusco ML.  Psychiatry Res. 2017 Mar 2;252:325-332.

This is a review of the important issue of depression in fathers.  Most of the reviewed studies suffer from methodological limitations, including the small sample, the lack of a structured psychiatric diagnosis, and inclusion bias. Despite such limitations, paternal depression seems to be associated with an increased risk of developmental and behavioural problems and psychopathology in the offspring.


Development and properties of a brief scale to assess intimate partner relationship in the postnatal period.

Wynter K, Tran TD, Rowe H, Fisher J.  J Affect Disord. 2017 Mar 14;215:56-61.

The Partner Interactions after Baby Scale is a 7-item scale which shows promise as a valid tool to assess life stage-specific, modifiable partner behaviours


Pregnancy and Electroconvulsive Therapy: A Multidisciplinary Approach.

Ray-Griffith SL, Coker JL, Rabie N, Eads LA, Golden KJ, Stowe ZN.  J ECT. 2016 Jun;32(2):104-12.

Case study and literature review of the use of ECT during pregnancy.


Prevalence of Perinatal Depression in the Military: A Systematic Review of the Literature.

Klaman SL, Turner K.  Matern Child Health J. 2016 Nov;20(Suppl 1):52-65.

 

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