Mass General Hospital

Harvard Medical School

Fertility and Mental Health

Mood disorders and Fertility

Baron M, Risch N, Mendlewicz J. Differential fertility in bipolar affective illness. J Affect Disord 1982; 4:103-12.

Choi SH, Shapiro H, Robinson GE, Irvine J, Neuman J, Rosen B, Murphy J, Stewart D. Psychological side-effects of clomiphene citrate and human menopausal gonadotropin. J Psychosom Obstet Gynaecol 2005; 26:93-100.

Grambsch P, Young EA, Meller WH. Pulsatile luteinizing hormone disruption in depression. Psychoneuroendocrinology 2004; 29:825-29.

Harlow BL, Wise LA, Otto MW, Soares CN, Cohen LS. Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and Cycles. Archives Gen Psychiatry 2003; Jan;60(1):29-36.

Joffe H, Kim DR, Foris JM, Baldassano CF, Gyulai L, Hwang CH, McLaughlin WL, Sachs GS, Thase ME, Harlow BL, Cohen LS. Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controls. J Clin Psychiatry 2006;67:297-304.

Meller WH, Zander KM, Crosby RD, Tagatz GE. Leuteinizing hormone pulse characteristics in depressed women. Am J Psychiatry 1997; 154:1454-5.

Odergard O. Fertility of psychiatric first admissions in Norway 1936-1975. Act Psychiatr Scand 1980; 62:212-220.

Williams KE, Marsh WK, Rasgon NL. Mood disorders and fertility in women: a critical review of the literature and implications for future research. Hum Reprod Update 2007; Nov-Dec;13(6):607-16.

Psychotroptic Medications and Fertility

Hemels EH, Einarson A, Koren G, Lanctôt KL, Einarson TR. Antidepressant Use During Pregnancy and the Rates of Sponaneous Abortions: A Meta-Analysis. Ann Pharmacother 2005; 39:803-809.

Haddad PM, Hellewell JS, Wieck A.. Antipsychotic induced hyperprolactinaemia: a series of illustrative case reports (letter). J Psychopharmacol 2001; 15: 293-295

Joffe H, Cohen LS, Suppes T, McLaughlin WL, Lavori P, Adams JM, Hwang CH, Hall JE, Sachs GS. Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder. Biol Psychiatry 2006: 59: 1078-1086.

Klock, SC, Sheinin, S, Kazer, R and Zhang, X. A pilot study of the relationship between selective serotonin reuptake inhibitors and in vitro fertilization outcome
Fertil Steril 2004; ( 82)4: 968-969.

Misra M, Papakostas GI, Klibanski A. Effects of psychiatric disorders and psychotropic medications on prolactin and bone metabolism. J Clin Psychiatry 2004; 65: 1607-1618.

Mood and Anxiety Disorders in Women with Infertility

Anderson KM. Sharpe M. Rattray A. Irvine DS. Distress and concerns in couples referred to a specialist infertility clinic. Journal of Psychosomatic Research 2003; 54(4):353-5.

Chen TH, Chang SP, Tsai CF, Juang KD: Prevalence of depressive and anxiety disorders in an assisted reproductive technique clinic. Hum Reprod 2004; 19:2313-18.

Demyttenaere K, Bonte L, Gheldof M, Vervaeke M, Meulman C, Vanderschuerem D, D’Hooghe T. Coping style and depression level influence outcome of in vitro infertilization. Fertil Steril 1998;68(6):1026-1033.

Domar AD, Broome A, Zuttermeister PC, Seibel M, Friedman R. The prevalence and predictability of depression in infertile women. Fertil Steril 1992;58(6):1158-1163.

Fassino S, Pierò A, Boggio S, Piccioni V, Garzaro L. Anxiety, depression and anger suppression in infertile couples: a controlled study. Hum Reprod 2002 Nov;17(11):2986-94.

Lukse MP, Vacc NA. Grief, depression, and coping in women undergoing infertility treatment. Obstet and Gynecol 1999;93(2):245-251.

Mindes EJK, Ingram KM, Kliewer W, James CA. Longitudinal analyses of the relationship between unsupportive social interactions and psychological adjustment among women with fertility problems. Soc Sci Med 2003; 56: 2165-2180.

Slade P, Emery J, Lieberman BA. A prospective, longitudinal study of emotions and relationships in in-vitro fertilization treatment. Human Reprod 1997; 12:183-190.

Smeenk JM, Verhaak CM, Eugster A, van Minnen A, Zielhuis GA, Braat DD. The effect of anxiety and depression on the outcome of in-vitro fertilization. Hum Reprod. 2001 Jul;16(7):1420-3.

Thiering P, Beaurepaire J, Jones M, Saunders D, Tennant C. Mood state as a predictor of treatment outcome after in vitro fertilization/embryo transfer technology (IVF/ET). J Psychosom Res 1993;5:481-491.

Psychological Impact of Infertility

Boivin J, Takefman JE, Tulandi T, Brender W. Reactions to infertility based on extent of treatment failure. Fertil Steril 1995 Apr;63(4):801-7.

Boivin J, Takefman JE. Stress level across stages of in vitro fertilization in subsequently pregnant and nonpregnant women. Fertil Steril 1995; 64:802-10.

Boivin J, Takefman JE. Impact of the in-vitro fertilization process on emotional, physical and relational variables. Hum Reprod 1996; 11:903-7.

Domar AD. Impact of psychological factors on dropout rates in insured infertility patients. Fertil Steril 2004;81(2):271-273.

Greil AL. Infertility and psychological distress: a critical review of the literature. Soc Sci Med 1997; 45:1679-1704.

Hammarberg K, Astbury J, Baker HWG. Women’s experience of IVF: a follow-up study. Hum Reprod 2001;16:374-383.

Harf-Kashdaei, E and Kaitz, M. Antenatal moods regarding self, baby, and spouse among women who conceived by in vitro fertilization
Fertil Steril 2007; 87(6): 1306-131.

Klock, SC and Greenfeld, DA Psychological status of in vitro fertilization patients during pregnancy: a longitudinal study
Fertil Steril 2006; (73)6:1159-1164.

Klonoff-Cohen H, Chu E, Natarajan L, Sieber W. A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer. Fertil Steril 2001; 76:675-87.

Olivius C, Friden B, Borg G, Bergh C. Why do couples discontinue in vitro fertilization treatment: a cohort study. Fertil Steril 2004;81:258-261.

Nachtigall RD, Becker G, Wozny M. The Effects of gender-specific diagnosis on men’s and women’s response to infertility. Fertil Steril 1992;57:113-21

Rajkhowa M, McConnell A, Thomas GE. Reasons for discontinuation of IVF treatment: a questionnaire study. Hum Reprod 2006; 21:358-63.

Sanders KA, Bruce NW. Psychosocial stress and treatment outcome following assisted reproductive technology. Hum Reprod. 1999 Jun;14(6):1656-62.

Verhaak CM, Smeenk JM, Evers AW, van Minnen A, Kremer JA, Kraaimaat FW. Predicting emotional response to unsuccessful fertility treatment: a prospective study. J Behav Med 2005; 28:181-90.

Verhaak CM, Smeenk JM, Evers AW, Kremer JA, Kraaimaat FW, Braat DD. Women’s emotional adjustment to IVF: a systematic review of 25 years of research. Hum Reprod Update. 2007 Jan-Feb;13(1):27-36.

Wright J, Duchesne C, Sabourin S, Bissonnette F, Benoit J, Girard Y. Psychological distress and infertility, men and women respond differently. Fertil Steril 1991; 55:100-108.

Psychological Interventions

Campagne DM. Should fertilization treatment start with reducing stress? Hum Reprod 2006; 21:1651-8.

De Liz TM, Strauss B: Differential efficacy of group and individual/couple psychotherapy with infertile patients. Hum Reprod 2005; 20:1324-32.

Domar AD, Clapp D, Slawsby EA, Dusek J, Kessel B, Freizinger M. Impact of group psychological interventions on pregnancy rates in infertile women. Fertil Steril 2000;73(4):805-811.

Domar AD, Zuttermeister PC, Seibel M, Benson H. Psychological improvement in infertile women after behavioral treatment: a replication. Fertil Steril 1992;58(1):144-147.

Domar AD: Psychological stress and infertility. UpToDate, Rose BD (Ed), 2007.

Domar AD, Seibel MM, Benson H. The mind/body program for infertility: A new behavioral treatment approach for women with infertility. Fertil Steril 1990; 53:246-9.

Facchinetti F, Tarabusi M, Volpe A. Cognitive- behavioral treatment decreases cardiovascular and neuroendocrine reaction to stress in women waiting for assisted reproduction. Psychoneuroendocrinology 2004; 29(2):162-173.

Lemmens GM, Vervaeke M, Enzlin P, Bakelants E, Vanderschueren D, D’Hooghe T, Demyttenaere K. Coping with infertility: a body-mind group intervention programme for infertile couples. Hum Reprod 2004; 19:1917-23.

Terzioglu, F. Investigation into effectiveness of counseling on assisted reproductive techniques in Turkey. J. Psychosom. Obstet. Gynecol 2001; 22, 133–141.

Psychotic Disorders and fertility

Howard LM. Fertility and pregnancy in women with psychotic disorders. Eur J Obstet Gynecol Reprod Biol 2005; 119:3-10.

Joffe H. Reproductive Biology and Psychotropic Treatments in Premenopausal Women with Bipolar Disorder. J Clin Psychiatry 2007; 68[Suppl9]: 10-15.

Eating Disorders and fertility

Stewart DE, Robinson E, Goldbloom DS, Wright C. Infertility and eating disorders. American Journal of Obstetrics and Gynecology 1990; 163: 1196-1999.

Ward VB. Eating Disorders in Pregnancy. BMJ 2008; 336: 93-96

Wolfe BE. Reproductive Health in Women with Eating Disorders. J of Ob Gyn and Neonatal Nursing 2004; 34(2): 255-263.

Mood stabilizers impact on oral contraceptives

Reimers A, Helde G, Brodtkorb E. Ethinyl estradiol, not progestogens reduces lamotrigine in serum concentrations. Epilepsia 2005; 46:1414-1417

Sabers A, Ohman I, Christensen J, Tomson T. Oral contraceptives reduce lamotrigine plasma levels. Neurology 2003; 6:570-571.

Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol 2006; 61:191-199.

 

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