Postpartum Psychiatric Disorders

Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under [...]

Psychological Distress in the Mother May Affect Levels of Immunoglobulins in Breast Milk

We have seen multiple studies which indicate that postpartum depression (PPD) interferes with breastfeeding.  Postpartum women who suffer from depression are less likely to breastfeed, and they typically breastfeed for a shorter duration than women who are not depressed.  A recent study looks at an entirely different question, asking whether postpartum stress affects the quality of the breast milk.  In this study, the researchers focused on levels of immunoglobulin A (IgA) in the breast milk.  (Immunoglobulins or antibodies are passed from the mother to the baby through the breast milk and help to confer immunity.)

Perinatal Dyadic Psychotherapy for the Treatment of Postpartum Depression

Many studies have observed that postpartum depression may negatively affect the mother-infant relationship and may thus impede bonding and attachment and negatively affect the development of the young child.  A recent study explores the use of Perinatal Dyadic Psychotherapy (PDP), a dual-focused mother-infant intervention designed to prevent and/or decrease depressive symptoms in the mother and to improve aspects of the mother-infant relationship related to child development.

Acupuncture for Postpartum Depression

85 women with postpartum depression were randomized to receive acupuncture plus psychological intervention (five sessions per week) or treatment with fluoxetine (20 mg per day). The two groups were treated continuously for six weeks. Depressive symptoms were measured using the Hamilton Depression scale (HAMD).