Menopause

Earlier Age of Surgical Menopause Associated with More Significant Cognitive Decline

Previous studies have shown that the abrupt hormonal changes that occur after a surgical menopause (i.e., removal of the ovaries) negatively affect cognition in women.  According to a recent study, "Women who were younger at the time of surgical menopause have a more rapid rate (steeper slope) of cognitive decline than women who were older at the time of surgery or than women undergoing natural menopause."  Earlier age at menopause was also associated with increased Alzheimer’s disease neuropathology, in particular neuritic plaques.