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Archive | menopause

Transdermal Estradiol, But Not Oral Estrogens, Improves Sexual Function in Postmenopausal Women

  Sexual dysfunction is common among peri- and postmenopausal women and include a spectrum of problems, including low (or hypoactive) sexual desire, decreased satisfaction, and discomfort.   Reports indicate that the prevalence of hypoactive sexual desire ranges from 9% in naturally postmenopausal women up to 26% in younger surgically postmenopausal women.  A recent study compares the […]

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In Brief: Night Sweats? Hot Flashes? Try Yoga

Yoga is frequently recommended as a treatment for menopause-related symptoms, including vasomotor symptoms and sleep disturbance; however, studies regarding its effectiveness have yielded mixed results. In a recent meta-anlsyis, researchers analyzed data from 13 randomized controlled trials with a total of 1306 participants. Compared with no treatment, yoga reduced total menopausal symptoms, and specifically led […]

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In Brief: Cognitive Behavioral Therapy Improves Sleep in Perimenopausal Women

Peri- and post-menopausal women frequently complain of insomnia or poor sleep quality. Sleep disturbance is often attributed to nocturnal hot flashes; however, a sizeable proportion of menopausal women may have a primary sleep disorder.    As part of the Menopause Strategies: Finding Lasting Answers for Symptoms and Health network (MS-FLASH), randomized clinical trials (RCTs) were used […]

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In Brief: Hormone Replacement Has No Impact on Mortality in Women

While there have been concerns regarding the risks associated with prolonged use of hormone replacement, an increasing number of studies suggest that the risk may be relatively low in certain populations and that hormone replacement is appropriate in certain settings.  A recent study published in JAMA has focused on mortality rates in women treated with […]

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Estrogen Receptor Modulator Raloxifene for Women with Schizophrenia

  Several years ago, we reviewed a paper suggesting that estrogen may have beneficial effects for women with schizophrenia.  In this study, women with schizophrenia were treated with estrogen in addition to their antipsychotic medications.  Adjunctive treatment with estrogen was associated with significant improvement in their positive symptoms (hallucinations, delusions), but the women experienced no […]

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What Exactly Causes Hot Flashes in Menopausal Women? Researchers Look at Neurokinin B

Perimenopausal vasomotor symptoms are triggered by a fall in circulating levels of estrogen and other sex steroids. It has been hypothesized that thermoregulatory centres in the hypothalamus play a crucial role in mediating the hot flash response. However, exactly how do hormonal changes bring about these changes in the hypothalamus?  If we could understand this […]

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Treatment Challenges in Menopausal Women with Schizophrenia

Over the years there have been multiple reports indicating that women with schizophrenia may experience worsening of their symptoms as they transition into the menopause.  In addition, while schizophrenia typically has its onset in young adulthood, there is a second peak in women around menopause.  Researchers have postulated that falling estrogen levels may modulate dopaminergic […]

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Photo by Christoph Lehmann

Earlier Age at Menopause Increases Risk of Depression

Estrogens have neuroprotective and antidepressant effects.  During the perimenopause, when estrogen levels fluctuate and then fall significantly, women are more vulnerable to depression and cognitive deficits.  A recent study has investigated the association between age at menopause and risk for depression in postmenopausal women with naturally occurring menopause. In this meta-analysis, data was obtained from […]

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New Research from the CWMH: Armodafinil for Menopause-Related Fatigue

Several recent articles indicate that the burden of menopausal symptoms is greater than generally perceived.  About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause phase.  For most, the symptoms are manageable, but for a sizeable subset of midlife women, these symptoms can negatively […]

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Position Paper: Non-Hormonal Treatments for Vasomotor Symptoms

A recent paper from the European Menopause and Andropause Society (EMAS) reviews non-hormonal therapy options for the treatment of  menopausal vasomotor symptoms. This EMAS position paper provides guidance for treaters managing peri- and postmenopausal women who cannot or do not want to use hormones to manage their symptoms.  While the information here is not new, […]

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