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Archive | depression

Pilot Study of Telephone-Delivered Interpersonal Therapy for Women with Postpartum Depression

It is clear that screening for perinatal depression substantially improves detection; however, screening alone does not appear to improve rates of treatment or outcomes.  What we find is that many, if not most, women with perinatal depression do not receive adequate care.  There appear to be many obstacles: stigma associated with mental illness, lack of […]

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Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under investigation for the treatment of refractory seizure disorders but it turned out to be a good antidepressant.  The information we […]

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Minimal Effects of Prenatal SSRIs on Motor Development in Exposed Children

When we meet with women to discuss the reproductive safety of antidepressant medications, one of the most challenging and anxiety-provoking aspects of the consultation is the discussion we have regarding the long-term effects of prenatal antidepressant exposure on the child.  Because studies assessing the effects of prenatal exposure to medication (or other environmental exposures) take […]

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SAGE-547 for depression: Cause for caution and optimism

The importance of postpartum depression, both in terms of its prevalence and the need for appropriate screening and effective treatments, has become an increasingly important area of focus for clinicians, patients, and policymakers. This derives from more than a decade of data on the significant prevalence of the condition, with roughly 10% of women meeting […]

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Prenatal SSRI Exposure and Speech/Language Disorders: Many Headlines, Little Risk

Last week, an article looking at the cognitive and motor development of children with prenatal exposure to antidepressants was published in JAMA Psychiatry.  Since that time, we have received a lot of questions regarding the article and the clinical implications of its findings.  When I did a quick Google search, I found 36 articles reviewing […]

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Credit: "Baby girl Hong Kong" by Foudeelau. Licensed CC BY-SA 3.0 via Wikimedia Commons -

Depression in Fathers Affects Bonding

Multiple studies have shown that postpartum depression can interfere with bonding between the mother and her infant. While new fathers may also develop depression, little is known about how depression in the father affects bonding. A recent study from Sweden has taken a look at the association between maternal and paternal depressive symptoms and parental […]

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Credit: Pregnant Woman from Wikimedia Commons

Brief Report: TMS for Depression During Pregnancy

Transcranial magnetic stimulation or TMS is similar to ECT but uses electromagnetic pulses to generate electrical current in specific regions of the brain that are known to modulate mood.  TMS is less likely to cause side effects and has thus been proposed as a possible alternative therapy for those suffering from treatment-resistant depression.  (You can […]

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Women with Recurrent Pregnancy Loss at Risk for Depression and Anxiety

In a recent cross-sectional study from Denmark, researchers compared the prevalence of stress and depressive symptoms among 301 women with recurrent pregnancy loss (or RPL) and 1813 women attempting to conceive naturally. RPL was defined as three or more pregnancy losses before 12 weeks’ gestation. The Major Depression Index (MDI) was used to assess symptoms […]

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More Pediatricians Are Screening for Postpartum Depression

An article published today in the US News and World Report discusses the expanded role pediatric health care providers are playing in screening new mothers for postpartum depression.  Because pediatricians have frequent contacts with the mother during the first year of a child’s life and because depression in the mother may negatively affect the child, the […]

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Baby Belly from Wikimedia Commons

SSRIs and Pregnancy: No Increase in Risk of Malformations

Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an […]

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