• Antidepressants and Pregnancy

    Another Study on Antidepressants and Birth Defects: Does it Change Our Decision-Making?

    Prozac (fluoxetine) was the first SSRI or selective serotonin reuptake inhibitor.  Since its release in 1988, we have been gathering data on the reproductive safety of fluoxetine and other SSRIs.  Over the last 32 years, [...]

    Clinical Update 2020: Antipsychotic Medications and Risk of Gestational Diabetes

    Given the number of younger women using atypical antipsychotic medications, there is an urgent need for more accurate data regarding the reproductive safety of these medications. One important question is whether these newer antipsychotic [...]

    Risk of Preterm Birth and Respiratory Distress in Pregnancies with Prenatal Exposure to Antidepressants

    From the OptumLabs Data Warehouse, researchers identified 226,932 singleton deliveries. Cases of antidepressant exposure were defined as pregnancies with prescription claims for antidepressants submitted between the last menstrual period and 35 weeks’ gestation.  To [...]

    Neurodevelopmental Outcomes in Kindergartners with Prenatal Exposure to Antidepressants

    While we have data to support the use of antidepressants, including the selective serotonin reuptake inhibitors (SSRIs) and the serotonin norepinephrine reuptake inhibitors (SNRIs), during pregnancy, most studies have focused on risk of congenital [...]

    Are Clinicians Using the PLLR to Guide Prescribing During Pregnancy?

    In 2015, the U.S. Food and Drug Administration (FDA) proposed major revisions to prescription drug labeling -- the Pregnancy and Lactation Labeling Rule or PLLR -- in order to provide more accurate and helpful [...]

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