Mass General Hospital

Harvard Medical School

Welcome to the MGH Center for Women’s Mental Health


Welcome to The Ammon-Pinizzotto Center for Women’s Mental Health at MGH. Our Center, established in 1989, has been renamed following the generous gift from Carol Ammon and Dr. Marie Pinizzotto. These resources will be used to realize the overarching mission of the Center.

This website provides a range of current information including discussion of new research findings in women’s mental health and how such investigations inform day-to-day clinical practice. Despite the growing number of studies being conducted in women’s health, the clinical implications of such work are frequently controversial, leaving patients with questions regarding the most appropriate path to follow. Providing these resources to patients and their doctors so that individual clinical decisions can be made in a thoughtful and collaborative fashion dovetails with the mission of our Center.

The National Pregnancy Registry for Psychiatric Medications:

All pregnant women ages 18-45 are eligible to enroll in the registry. The primary goal of this Registry is to determine the frequency of major malformations, such as heart defects, cleft lip, or neural tube defects, in infants exposed to atypical antipsychotics and antidepressants during pregnancy.  We are currently seeking both controls and those being treated with atypical antipsychotics and/ or antidepressants. For more information, please visit this page, call 1-866-961-2388 or e-mail


 EnBrace HR for MDD Relapse Prevention in         Women Trying to Conceive and Early Pregnancy:


Are you pregnant or planning a pregnancy? Do you feel depressed or have a history of depression? If you are less than 28 weeks pregnant or trying to conceive and have experienced depression now or in the past, you may be eligible to take part in a research study for the treatment of depression with a prenatal supplement. For more information, please visit this page, call Gina at 617-643-9284 or e-mail



Lifestyle Intervention Research Study Opportunity:

Are you pregnant or planning to become pregnant? Do you have a history of depression? Do you want to lose weight or have a healthier lifestyle? You may be eligible to participate in a research study evaluating a new lifestyle intervention for weight loss. Participants will receive 10 sessions of therapy at no cost to you.

If you are interested in participating or would like additional information, please call Samantha at 617-643-2076.


The MGH Center for Women’s Mental Health

Perinatal and Reproductive Psychiatry Program

Simches Research Building

185 Cambridge St Suite 2200

Boston, MA 02114


To make an appointment:

Massachusetts General Hospital Clinical Program: (617) 724-7792

Location of appointments: 

Wang Ambulatory Care Center, Massachusetts General Hospital

15 Parkman St., Floor 8

Boston, MA 02114-3117 

Latest News from our Blog

  • New Study at the CWMH: Brexanolone (SAGE-547) for Postpartum Depression

    June 22, 2017

    In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is a new type of antidepressant: a formulation of allopregnanolone, which is an endogenous, naturally occurring neuroactive steroid and a metabolite of progesterone.  Data from the most recent study of brexanolone was ...

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  • In Brief: Problem-Solving Education Intervention Reduces Risk of Postpartum Depression

    June 20, 2017

      While many women are at risk for postpartum depression, we continue to struggle in providing adequate support and care to women in this setting, especially socioeconomically disadvantaged women.   In a randomized clinical trial including 230 Head Start mothers, those receiving problem-solving education (PSE) were 60% less likely to develop postpartum depression than those receiving standard ...

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  • New Research from the CWMH: Lithium During Pregnancy and Risk of Cardiovascular Malformations

    June 19, 2017

      While we use lithium less commonly now than we have in the past, lithium is still one of the very best mood stabilizers we have.  And with regard to its reproductive safety, we have studies going back nearly 50 years.   In the 1970s, reports from the International Register of Lithium Babies suggested a very strong ...

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  • Weekly Roundup for June 16, 2017: Recent Publications in Women’s Mental Health

    June 16, 2017

    This roundup has some really interesting and clinically relevant  articles.  The first one, from Palomo and colleagues, evaluates risk for cardiovascular malformations in children prenatally exposed to lithium.  Yang and colleagues look at neonatal discontinuation symptoms in children exposed to SNRIs and SSRIs and conclude that they are more related to prematurity than to exposure ...

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  • New Study Questions Prolonged Room-Sharing for Infants

    June 14, 2017

    In 2016, the American Academy of Pediatrics (AAP) issued new infant sleep guidelines,  recommending that  infants should sleep in the same room as their parents – on a separate firm sleep surface, such as a crib or bassinet — to decrease the risk of SIDS and other sleep-related deaths.  The following 19 recommendations are based ...

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  • Does Baby-Friendly Have to Be Mom-Unfriendly?

    June 12, 2017

    We’ve all heard it: Breast is Best.  We all know what it means.  And if you have had a baby at some point over the last ten years, you have been encouraged, and maybe even pressured, to breastfeed your baby.  Breastfeeding has become the foundation of what it means to be a good mother, and ...

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